Literature DB >> 21490098

Improved antigen yield in pandemic H1N1 (2009) candidate vaccine viruses with chimeric hemagglutinin molecules.

Ruth Harvey1, Kate A Guilfoyle, Sarah Roseby, James S Robertson, Othmar G Engelhardt.   

Abstract

The candidate pandemic H1N1 vaccine virus NIBRG-121 was derived by reverse genetics and comprises the hemagglutinin (HA) and neuraminidase (NA) genes from A/California/7/2009 (CAL) on an A/Puerto Rico/8/34 (PR8) backbone. NIBRG-121 was found to grow poorly in eggs, compared to seasonal H1N1 candidate vaccine viruses. Based on our previous study with H5N1 candidate vaccine viruses, we generated two new viruses with chimeric PR8/CAL HA genes. Here we show that these new viruses have considerably improved growth in eggs and are therefore better candidate vaccine viruses for use in production of pandemic H1N1 (2009) vaccine.

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Year:  2011        PMID： 21490098      PMCID： PMC3126323          DOI： 10.1128/JVI.00096-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  The development of vaccine viruses against pandemic A(H1N1) influenza.

Authors:  James S Robertson; Carolyn Nicolson; Ruth Harvey; Rachel Johnson; Diane Major; Kate Guilfoyle; Sarah Roseby; Robert Newman; Rebecca Collin; Chantal Wallis; Othmar G Engelhardt; John M Wood; Jianhua Le; Ramanunninair Manojkumar; Barbara A Pokorny; Jeanmarie Silverman; Rene Devis; Doris Bucher; Erin Verity; Catherine Agius; Sarina Camuglia; Chi Ong; Steven Rockman; Anne Curtis; Peter Schoofs; Olga Zoueva; Hang Xie; Xing Li; Zhengshi Lin; Zhiping Ye; Li-Mei Chen; Eduardo O'Neill; Amanda Balish; Aleksandr S Lipatov; Zhu Guo; Irina Isakova; Charles T Davis; Pierre Rivailler; Kortney M Gustin; Jessica A Belser; Taronna R Maines; Terrence M Tumpey; Xiyan Xu; Jacqueline M Katz; Alexander Klimov; Nancy J Cox; Ruben O Donis
Journal:  Vaccine       Date:  2011-01-01       Impact factor: 3.641

2.  Improved haemagglutinin antigen content in H5N1 candidate vaccine viruses with chimeric haemagglutinin molecules.

Authors:  Ruth Harvey; Carolyn Nicolson; Rachel E Johnson; Kate A Guilfoyle; Diane L Major; James S Robertson; Othmar G Engelhardt
Journal:  Vaccine       Date:  2010-10-08       Impact factor: 3.641

3.  Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions.

Authors:  Glenn A Marsh; Raheleh Hatami; Peter Palese
Journal:  J Virol       Date:  2007-07-18       Impact factor: 5.103

4.  Optimizing viral protein yield of influenza virus strain A/Vietnam/1203/2004 by modification of the neuraminidase gene.

Authors:  Joan E Adamo; Teresa Liu; Falko Schmeisser; Zhiping Ye
Journal:  J Virol       Date:  2009-02-18       Impact factor: 5.103

5.  An improved single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen: application for potency determinations of inactivated whole virus and subunit vaccines.

Authors:  J M Wood; G C Schild; R W Newman; V Seagroatt
Journal:  J Biol Stand       Date:  1977

6.  Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality system.

Authors:  Carolyn Nicolson; Diane Major; John M Wood; James S Robertson
Journal:  Vaccine       Date:  2005-04-22       Impact factor: 3.641

7.  Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics.

Authors:  Kanta Subbarao; Hualan Chen; David Swayne; Louise Mingay; Ervin Fodor; George Brownlee; Xiyan Xu; Xiuhua Lu; Jacqueline Katz; Nancy Cox; Yumiko Matsuoka
Journal:  Virology       Date:  2003-01-05       Impact factor: 3.616

8.  Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1).

Authors:  Ruth Harvey; Jun X Wheeler; Chantal L Wallis; James S Robertson; Othmar G Engelhardt
Journal:  Vaccine       Date:  2008-12-02       Impact factor: 3.641
  8 in total
  10 in total

1.  Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Authors:  Nicholas C Wu; Jia Xie; Tianqing Zheng; Corwin M Nycholat; Geramie Grande; James C Paulson; Richard A Lerner; Ian A Wilson
Journal:  Cell Host Microbe       Date:  2017-06-14       Impact factor: 21.023

2.  Error-prone pcr-based mutagenesis strategy for rapidly generating high-yield influenza vaccine candidates.

Authors:  Jianqiang Ye; Feng Wen; Yifei Xu; Nan Zhao; Liping Long; Hailiang Sun; Jialiang Yang; Jim Cooley; G Todd Pharr; Richard Webby; Xiu-Feng Wan
Journal:  Virology       Date:  2015-04-17       Impact factor: 3.616

3.  Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected].

Authors:  Rachel E Johnson; Michelle Hamill; Ruth Harvey; Carolyn Nicolson; James S Robertson; Othmar G Engelhardt
Journal:  PLoS One       Date:  2012-05-11       Impact factor: 3.240

4.  Identification of Influenza A/PR/8/34 Donor Viruses Imparting High Hemagglutinin Yields to Candidate Vaccine Viruses in Eggs.

Authors:  Adam Johnson; Li-Mei Chen; Emily Winne; Wanda Santana; Maureen G Metcalfe; Guaniri Mateu-Petit; Callie Ridenour; M Jaber Hossain; Julie Villanueva; Sherif R Zaki; Tracie L Williams; Nancy J Cox; John R Barr; Ruben O Donis
Journal:  PLoS One       Date:  2015-06-11       Impact factor: 3.240

5.  Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments.

Authors:  Ahmed Mostafa; Pumaree Kanrai; Henning Petersen; Sherif Ibrahim; Silke Rautenschlein; Stephan Pleschka
Journal:  PLoS One       Date:  2015-01-23       Impact factor: 3.240

6.  Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses.

Authors:  Kaitlyn Waters; Cheng Gao; Matthew Ykema; Lei Han; Lynden Voth; Yizhi Jane Tao; Xiu-Feng Wan
Journal:  PLoS Pathog       Date:  2021-10-07       Impact factor: 6.823

7.  Transformation of Dunaliella salina by Agrobacterium tumefaciens for the Expression of the Hemagglutinin of Avian Influenza Virus H5.

Authors:  Inkar Castellanos-Huerta; Gabriela Gómez-Verduzco; Guillermo Tellez-Isaias; Guadalupe Ayora-Talavera; Bernardo Bañuelos-Hernández; Víctor Manuel Petrone-García; Gilberto Velázquez-Juárez; Isidro Fernández-Siurob
Journal:  Microorganisms       Date:  2022-02-04

8.  Development of high-yield influenza A virus vaccine viruses.

Authors:  Jihui Ping; Tiago J S Lopes; Chairul A Nidom; Elodie Ghedin; Catherine A Macken; Adam Fitch; Masaki Imai; Eileen A Maher; Gabriele Neumann; Yoshihiro Kawaoka
Journal:  Nat Commun       Date:  2015-09-02       Impact factor: 14.919

9.  Kinetics of pulmonary immune cells, antibody responses and their correlations with the viral clearance of influenza A fatal infection in mice.

Authors:  Jin Lv; Yanhong Hua; Dan Wang; Aofei Liu; Juan An; Aimin Li; Yanfeng Wang; Xiliang Wang; Na Jia; Qisheng Jiang
Journal:  Virol J       Date:  2014-03-26       Impact factor: 4.099

10.  Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses.

Authors:  Saira Hussain; Matthew L Turnbull; Helen M Wise; Brett W Jagger; Philippa M Beard; Kristina Kovacikova; Jeffery K Taubenberger; Lonneke Vervelde; Othmar G Engelhardt; Paul Digard
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103
  10 in total

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