| Literature DB >> 21489802 |
Ahmed Kamal1, B Ashwini Kumar, Paidakula Suresh, Aarti Juvekar, Surekha Zingde.
Abstract
A series of new 4β-carbamoyl epipodophyllotoxin analogues have been synthesized and evaluated for their anticancer activity against eleven cancer cell lines including Zr-75-1, MCF7, KB, Gurav, DWD, Colo 205, A-549, Hop62, PC3, SiHa and A-2780. Most of the compounds exhibited better growth-inhibition activities against tested cell lines than that of etoposide. Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide.Entities:
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Year: 2011 PMID： 21489802 DOI： 10.1016/j.bmc.2011.03.030
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641