OBJECTIVES: We assessed the incidence and clinical characteristics of acute kidney injury (AKI) in critically ill patients infected with pandemic influenza A (H1N1) and its effect on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with pandemic H1N1-related critical illness admitted to intensive care units (ICUs) of 28 tertiary or referral hospitals in South Korea between September 1, 2009, and February 28, 2010. Outcomes were AKI within 72 hours after ICU admission and 30-day mortality. Acute kidney injury was defined according to the Risk, Injury, Failure, Loss, and End-stage renal failure criteria. RESULTS: Of the 221 patients, 50 (22.6%) developed AKI within 72 hours after ICU admission. Independent risk factors for AKI were age (odds ratio [OR], 1.05; P = .003), chronic kidney disease (OR, 14.82; P = .004), and Sequential Organ Failure Assessment score (OR, 1.45; P < .001). Age (OR, 1.04; P = .003), Sequential Organ Failure Assessment score (OR, 1.28; P = .012), state of immune suppression (OR, 4.09; P = .01), mechanical ventilation (OR, 18.24; P = .001), corticosteroid use (OR, 3.09; P = .007), and AKI (OR, 2.86; P = .035) were significantly associated with 30-day mortality. CONCLUSIONS: A significant number of patients with H1N1-related critical illness developed AKI within 72 hours of ICU admission, and this early development of AKI was associated with 30-day mortality. Crown
OBJECTIVES: We assessed the incidence and clinical characteristics of acute kidney injury (AKI) in critically illpatients infected with pandemic influenza A (H1N1) and its effect on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with pandemic H1N1-related critical illness admitted to intensive care units (ICUs) of 28 tertiary or referral hospitals in South Korea between September 1, 2009, and February 28, 2010. Outcomes were AKI within 72 hours after ICU admission and 30-day mortality. Acute kidney injury was defined according to the Risk, Injury, Failure, Loss, and End-stage renal failure criteria. RESULTS: Of the 221 patients, 50 (22.6%) developed AKI within 72 hours after ICU admission. Independent risk factors for AKI were age (odds ratio [OR], 1.05; P = .003), chronic kidney disease (OR, 14.82; P = .004), and Sequential Organ Failure Assessment score (OR, 1.45; P < .001). Age (OR, 1.04; P = .003), Sequential Organ Failure Assessment score (OR, 1.28; P = .012), state of immune suppression (OR, 4.09; P = .01), mechanical ventilation (OR, 18.24; P = .001), corticosteroid use (OR, 3.09; P = .007), and AKI (OR, 2.86; P = .035) were significantly associated with 30-day mortality. CONCLUSIONS: A significant number of patients with H1N1-related critical illness developed AKI within 72 hours of ICU admission, and this early development of AKI was associated with 30-day mortality. Crown
Authors: Shruti Gupta; Steven G Coca; Lili Chan; Michal L Melamed; Samantha K Brenner; Salim S Hayek; Anne Sutherland; Sonika Puri; Anand Srivastava; Amanda Leonberg-Yoo; Alexandre M Shehata; Jennifer E Flythe; Arash Rashidi; Edward J Schenck; Nitender Goyal; S Susan Hedayati; Rajany Dy; Anip Bansal; Ambarish Athavale; H Bryant Nguyen; Anitha Vijayan; David M Charytan; Carl E Schulze; Min J Joo; Allon N Friedman; Jingjing Zhang; Marie Anne Sosa; Eric Judd; Juan Carlos Q Velez; Mary Mallappallil; Roberta E Redfern; Amar D Bansal; Javier A Neyra; Kathleen D Liu; Amanda D Renaghan; Marta Christov; Miklos Z Molnar; Shreyak Sharma; Omer Kamal; Jeffery Owusu Boateng; Samuel A P Short; Andrew J Admon; Meghan E Sise; Wei Wang; Chirag R Parikh; David E Leaf Journal: J Am Soc Nephrol Date: 2020-10-16 Impact factor: 10.121