Ying Li1, Honghao Wang, Youming Long, Zhengqi Lu, Xueqiang Hu. 1. MS Clinical Research Center, Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Abstract
OBJECT: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS). PATIENTS AND METHODS: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits. RESULTS: Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased. CONCLUSIONS: Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17.
OBJECT: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS). PATIENTS AND METHODS: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits. RESULTS: Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased. CONCLUSIONS: Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17.
Authors: Ulisses C Linhares; Patrícia B Schiavoni; Priscila O Barros; Taissa M Kasahara; Bruna Teixeira; Thais B Ferreira; Regina Alvarenga; Joana Hygino; Morgana M M Vieira; Vera Carolina B Bittencourt; Regis M Andrade; Arnaldo F Andrade; Cleonice A M Bento Journal: J Clin Immunol Date: 2012-09-05 Impact factor: 8.317