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Literature DB >> 2148912

In vivo evidence that human atrial natriuretic factor-(99-126) (hANF) stimulates parasympathetic activity in man.

S Zeuzem¹, H G Olbrich, T Haak, E Jungmann.

Abstract

In a double-blind study 8 healthy male subjects received 100 micrograms human atrial natriuretic facotr-(99-126) (hANF) and NaCl0.9% in random order on different days. Following hANF injection a significant increase in cardiac beat-to-beat variation was observed (4.65% vs 5.95%). This shows that in vivo human atrial natriuretic factor stimulates cardiac parasympathetic activity in man.

Entities: Chemical Gene Species

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Year: 1990 PMID： 2148912 DOI： 10.1007/bf02657063

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

19 in total

1. alpha-ANP alters reflex control of lumbar and renal sympathetic nerve activity and heart rate.

Authors: T Imaizumi; A Takeshita; H Higashi; M Nakamura
Journal: Am J Physiol Date: 1987-11

2. Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas.

Authors: C B Saper; D G Standaert; M G Currie; D Schwartz; D M Geller; P Needleman
Journal: Science Date: 1985-03-01 Impact factor: 47.728

3. Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers.

Authors: A M Richards; M G Nicholls; H Ikram; M W Webster; T G Yandle; E A Espiner
Journal: Lancet Date: 1985-03-09 Impact factor: 79.321

4. Assessment of parasympathetic control of heart rate by a noninvasive method.

Authors: F M Fouad; R C Tarazi; C M Ferrario; S Fighaly; C Alicandri
Journal: Am J Physiol Date: 1984-06

5. Cardiac autonomic neuropathy in diabetes: comparison of measures of R-R interval variation.

Authors: D J Ewing; D Q Borsey; F Bellavere; B F Clarke
Journal: Diabetologia Date: 1981-07 Impact factor: 10.122

6. Cardiac denervation in diabetes.

Authors: T Wheeler; P J Watkins
Journal: Br Med J Date: 1973-12-08

7. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man.

Authors: M A Pfeifer; D Cook; J Brodsky; D Tice; A Reenan; S Swedine; J B Halter; D Porte
Journal: Diabetes Date: 1982-04 Impact factor: 9.461

8. Immunocytochemical evidence for CDD/ANP-like peptides in strands of myoendocrine cells associated with the ventricular conduction system of the rat heart.

Authors: H Back; W E Stumpf; E Ando; K Nokihara; W G Forssmann
Journal: Anat Embryol (Berl) Date: 1986

In vivo evidence that human atrial natriuretic factor-(99-126) (hANF) stimulates parasympathetic activity in man.

1. alpha-ANP alters reflex control of lumbar and renal sympathetic nerve activity and heart rate.

2. Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas.

3. Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers.

4. Assessment of parasympathetic control of heart rate by a noninvasive method.

5. Cardiac autonomic neuropathy in diabetes: comparison of measures of R-R interval variation.

6. Cardiac denervation in diabetes.

7. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man.

8. Immunocytochemical evidence for CDD/ANP-like peptides in strands of myoendocrine cells associated with the ventricular conduction system of the rat heart.

9. Presence of an atrial natriuretic factor-like peptide in the rat superior cervical ganglia.

10. Activation of vagal depressor reflexes by atriopeptins inhibits renal sympathetic nerve activity.

Review 1. Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.

2. Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.

3. Direct chronotropic effects of atrial and C-type natriuretic peptides in anaesthetized dogs.

4. Muscarinic effect of atrial natriuretic peptide on rabbit airways.