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Literature DB >> 21488902

Regulatory T cells and Foxp3.

Abstract

Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune-mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.

Entities: Chemical

Mesh：

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Year: 2011 PMID： 21488902 PMCID： PMC3077798 DOI： 10.1111/j.1600-065X.2011.01018.x

Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988

77 in total

1. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

Authors: Luke M Williams; Alexander Y Rudensky
Journal: Nat Immunol Date: 2007-01-14 Impact factor: 25.606

2. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

Authors: Meixiao Long; Sung-Gyoo Park; Ian Strickland; Matthew S Hayden; Sankar Ghosh
Journal: Immunity Date: 2009-12-18 Impact factor: 31.745

3. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

Authors: E Suri-Payer; A Z Amar; A M Thornton; E M Shevach
Journal: J Immunol Date: 1998-02-01 Impact factor: 5.422

4. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.

Authors: Madhav D Sharma; De-Yan Hou; Babak Baban; Pandelakis A Koni; Yukai He; Phillip R Chandler; Bruce R Blazar; Andrew L Mellor; David H Munn
Journal: Immunity Date: 2010-12-09 Impact factor: 31.745

5. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.

Authors: Guillaume Oldenhove; Nicolas Bouladoux; Elizabeth A Wohlfert; Jason A Hall; David Chou; Liliane Dos Santos; Shaun O'Brien; Rebecca Blank; Erika Lamb; Sundar Natarajan; Robin Kastenmayer; Christopher Hunter; Michael E Grigg; Yasmine Belkaid
Journal: Immunity Date: 2009-11-05 Impact factor: 31.745

6. Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells.

Authors: Guo-Yun Chen; Chong Chen; Lizhong Wang; Xing Chang; Pan Zheng; Yang Liu
Journal: J Immunol Date: 2008-04-15 Impact factor: 5.422

7. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.

Authors: Lizhong Wang; Runhua Liu; Weiquan Li; Chong Chen; Hiroto Katoh; Guo-Yun Chen; Beth McNally; Lin Lin; Penghui Zhou; Tao Zuo; Kathleen A Cooney; Yang Liu; Pan Zheng
Journal: Cancer Cell Date: 2009-10-06 Impact factor: 31.743

8. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila.

Authors: Frédéric Bantignies; Charlotte Grimaud; Sergey Lavrov; Mathieu Gabut; Giacomo Cavalli
Journal: Genes Dev Date: 2003-10-01 Impact factor: 11.361

9. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.

Authors: Xing Chang; Jian Xin Gao; Qi Jiang; Jing Wen; Nick Seifers; Lishan Su; Virginia L Godfrey; Tao Zuo; Pan Zheng; Yang Liu
Journal: J Exp Med Date: 2005-10-17 Impact factor: 14.307

10. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells.

Authors: Dipayan Rudra; Takeshi Egawa; Mark M W Chong; Piper Treuting; Dan R Littman; Alexander Y Rudensky
Journal: Nat Immunol Date: 2009-09-20 Impact factor: 25.606

294 in total

1. Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells.

Authors: E Ilker Ozay; Sudarvili Shanthalingam; Joe A Torres; Barbara A Osborne; Gregory N Tew; Lisa M Minter
Journal: Mol Ther Date: 2020-06-15 Impact factor: 11.454

2. Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain-Barré syndrome patients.

Authors: Mohan S Maddur; Magalie Rabin; Pushpa Hegde; Francis Bolgert; Moneger Guy; Jean-Michel Vallat; Laurent Magy; Jagadeesh Bayry; Srini V Kaveri
Journal: Immunol Res Date: 2014-12 Impact factor: 2.829

3. DNA methylation in inflammatory genes among children with obstructive sleep apnea.

Authors: Jinkwan Kim; Rakesh Bhattacharjee; Abdelnaby Khalyfa; Leila Kheirandish-Gozal; Oscar Sans Capdevila; Yang Wang; David Gozal
Journal: Am J Respir Crit Care Med Date: 2011-11-10 Impact factor: 21.405

Review 4. Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers.

Authors: Megan E Himmel; Yu Yao; Paul C Orban; Theodore S Steiner; Megan K Levings
Journal: Immunology Date: 2012-06 Impact factor: 7.397

5. Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2.

Authors: James D Lord; Karine Valliant-Saunders; Hejin Hahn; Richard C Thirlby; Steven F Ziegler
Journal: Dig Dis Sci Date: 2012-06-27 Impact factor: 3.199

Review 6. Immune checkpoints in central nervous system autoimmunity.

Authors: Nicole Joller; Anneli Peters; Ana C Anderson; Vijay K Kuchroo
Journal: Immunol Rev Date: 2012-07 Impact factor: 12.988

7. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

Authors: Sheng Xiao; Craig R Brooks; Chen Zhu; Chuan Wu; Johanna M Sweere; Sonia Petecka; Ada Yeste; Francisco J Quintana; Takaharu Ichimura; Raymond A Sobel; Joseph V Bonventre; Vijay K Kuchroo
Journal: Proc Natl Acad Sci U S A Date: 2012-07-05 Impact factor: 11.205