Literature DB >> 21488692

Backbone alignment modeling of the structure-activity relationships of opioid ligands.

Zhijun Wu1, Victor J Hruby.   

Abstract

Opioid studies are an important area of modern medicinal chemistry research. In this study we have provided innovative considerations to some long-standing problems in opioid studies, specifically the opioid pharmacophore and the potential binding modes of opioid ligands. Based on a new peptide backbone-alignment concept that we have developed along with this study, we discuss a wide variety of opioid ligands with respect to their structure-activity relationships.

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Year:  2011        PMID： 21488692     DOI： 10.1021/ci2000852

Source DB:  PubMed          Journal:  J Chem Inf Model        ISSN： 1549-9596            Impact factor:   4.956


  3 in total

1.  Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.

Authors:  Srinivas Deekonda; David Rankin; Peg Davis; Josephine Lai; Todd W Vanderah; Frank Porecca; Victor J Hruby
Journal:  Bioorg Med Chem       Date:  2015-11-23       Impact factor: 3.641

2.  Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism.

Authors:  Yeon Sun Lee; Michael Remesic; Cyf Ramos-Colon; Zhijun Wu; Justin LaVigne; Gabriella Molnar; Dagmara Tymecka; Aleksandra Misicka; John M Streicher; Victor J Hruby; Frank Porreca
Journal:  Biomedicines       Date:  2021-05-31

3.  Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands.

Authors:  Zhijun Wu; Victor J Hruby
Journal:  ACS Omega       Date:  2019-10-09
  3 in total

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