Literature DB >> 21487480

Visual analytics for immunologists: Data compression and fractal distributions.

Elena N Naumova1.   

Abstract

Visual analytics is the science of analytical reasoning that facilitates research through the use of interactive visual interfaces. New techniques of visual analytics are designed to aid the understanding of complex systems versus traditional blind-context rules to explore massive volumes of interrelated data. Nowhere else is visualization more important in analysis than in the emerging fields of life sciences, where amounts of collected data grow increasingly in exponential rates.The complexity of the immune system in immunology makes visual analytics especially important for understanding how this system works. In this context, our effort should be focused on avoiding accurate but potentially misleading use of visual interfaces. The proposed approach of data compression and visualization that reveal structural and functional features of immune responses enhances systemic and comprehensive description and provides the platform for hypothesis generation. Further, this approach can evolve into a powerful visual-analytical tool for prospective and real-time monitoring and can provide an intuitive and interpretable illustration of vital dynamics that govern immune responses in an individual and populations.The undertaken explorations demonstrate the critical role of novel techniques of visual analytics in stimulating research in immunology and other life sciences and in leading us to understanding of complex biological systems and processes.

Year:  2010        PMID: 21487480      PMCID: PMC3047786          DOI: 10.4161/self.1.3.12876

Source DB:  PubMed          Journal:  Self Nonself        ISSN: 1938-2030


  6 in total

1.  A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses.

Authors:  Yuri N Naumov; Elena N Naumova; Kevin T Hogan; Liisa K Selin; Jack Gorski
Journal:  J Immunol       Date:  2003-04-15       Impact factor: 5.422

2.  Simulation studies for a multistage dynamic process of immune memory response to influenza: experiment in silico.

Authors:  Elena N Naumova; Jack Gorski; Yuri N Naumov
Journal:  Ann Zool Fennici       Date:  2008-01-01       Impact factor: 1.324

3.  Complex T cell memory repertoires participate in recall responses at extremes of antigenic load.

Authors:  Yuri N Naumov; Elena N Naumova; Shalyn C Clute; Levi B Watkin; Kalyani Kota; Jack Gorski; Liisa K Selin
Journal:  J Immunol       Date:  2006-08-01       Impact factor: 5.422

4.  Two compensatory pathways maintain long-term stability and diversity in CD8 T cell memory repertoires.

Authors:  Elena N Naumova; Jack Gorski; Yuri N Naumov
Journal:  J Immunol       Date:  2009-07-27       Impact factor: 5.422

5.  A class I MHC-restricted recall response to a viral peptide is highly polyclonal despite stringent CDR3 selection: implications for establishing memory T cell repertoires in "real-world" conditions.

Authors:  Y N Naumov; K T Hogan; E N Naumova; J T Pagel; J Gorski
Journal:  J Immunol       Date:  1998-03-15       Impact factor: 5.422

6.  A clonotype nomenclature for T cell receptors.

Authors:  Maryam B Yassai; Yuri N Naumov; Elena N Naumova; Jack Gorski
Journal:  Immunogenetics       Date:  2009-07-01       Impact factor: 2.846

  6 in total
  3 in total

Review 1.  A review of analytics and clinical informatics in health care.

Authors:  Allan F Simpao; Luis M Ahumada; Jorge A Gálvez; Mohamed A Rehman
Journal:  J Med Syst       Date:  2014-04-03       Impact factor: 4.460

2.  Functional Annotation Analytics of Rhodopseudomonas palustris Genomes.

Authors:  Shaneka S Simmons; Raphael D Isokpehi; Shyretha D Brown; Donee L McAllister; Charnia C Hall; Wanaki M McDuffy; Tamara L Medley; Udensi K Udensi; Rajendram V Rajnarayanan; Wellington K Ayensu; Hari H P Cohly
Journal:  Bioinform Biol Insights       Date:  2011-09-21

3.  Food and Nutrition Systems Dashboards: A Systematic Review.

Authors:  Bingjie Zhou; Shiwei Liang; Kyle M Monahan; Gitanjali M Singh; Ryan B Simpson; Julia Reedy; Jianyi Zhang; Annie DeVane; Melissa S Cruz; Anastasia Marshak; Dariush Mozaffarian; Dantong Wang; Iaroslava Semenova; Ivan Montoliu; Daniela Prozorovscaia; Elena N Naumova
Journal:  Adv Nutr       Date:  2022-06-01       Impact factor: 11.567

  3 in total

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