Literature DB >> 21486707

It is time to remove the 'benign' from the essential tremor label.

Elan D Louis1, Michael S Okun.   

Abstract

In recent years, studies of essential tremor (ET) have demonstrated that the disease is associated with functionally-relevant cognitive abnormalities, a mood disturbance and other psychiatric co-morbidities, a functionally significant gait disorder, hearing deficits, and a variety of types of tremor. The tremor has been shown to be progressive in nature and quite disabling for a large number of sufferers. Also, recent clinical-epidemiological studies have linked prevalent ET to other neurodegenerative diseases and at least one study has demonstrated an increased risk of mortality in an ET cohort. While many of these studies are derived from clinic-based samples, population-based studies have also substantiated these findings, suggesting that even in the general population, the disease is associated with disability and with co-morbidity. Based on these available studies, it would seem inaccurate to append the word "benign" to ET. Not unlike the word "essential" itself, the word "benign" is an antiquated and outdated term that reflects an era where little was understood about ET. Historically, the general doctors who frequently encountered the disorder would educate patients that it was a benign, non-progressive condition not associated with any co-morbidity or risk of long-term worry. This notion, conceived by prior generations of physicians, is now known to be inaccurate. It is therefore our recommendation that the medical community open the dialog to consider formally discontinuing this nosology ("benign essential tremor") and to adopt the use of the term "essential tremor." Use of the word "benign" is a mischaracterization of the disease course, and could be prove misleading especially in the evolving doctor-patient relationship. In those cases with currently-mild tremor, the nosology "mild essential tremor" would be a more accurate reflection of disease.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21486707      PMCID: PMC3137726          DOI: 10.1016/j.parkreldis.2011.03.012

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN: 1353-8020            Impact factor:   4.891


  50 in total

1.  Cognitive and motor functional activity in non-demented community-dwelling essential tremor cases.

Authors:  Elan D Louis; Julián Benito-León; Saturio Vega-Quiroga; Félix Bermejo-Pareja
Journal:  J Neurol Neurosurg Psychiatry       Date:  2010-06-14       Impact factor: 10.154

2.  Frontal lobe dysfunction in essential tremor: a preliminary study.

Authors:  M Gasparini; V Bonifati; E Fabrizio; G Fabbrini; L Brusa; G L Lenzi; G Meco
Journal:  J Neurol       Date:  2001-05       Impact factor: 4.849

Review 3.  How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor.

Authors:  Elan D Louis; Joaquim J Ferreira
Journal:  Mov Disord       Date:  2010-04-15       Impact factor: 10.338

4.  Characteristics of social phobia among persons with essential tremor.

Authors:  F R Schneier; L F Barnes; S M Albert; E D Louis
Journal:  J Clin Psychiatry       Date:  2001-05       Impact factor: 4.384

5.  Cognitive deficits in patients with essential tremor.

Authors:  W J Lombardi; D J Woolston; J W Roberts; R E Gross
Journal:  Neurology       Date:  2001-09-11       Impact factor: 9.910

6.  Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.

Authors:  J A Obeso; C W Olanow; M C Rodriguez-Oroz; P Krack; R Kumar; A E Lang
Journal:  N Engl J Med       Date:  2001-09-27       Impact factor: 91.245

7.  Faster rate of cognitive decline in essential tremor cases than controls: a prospective study.

Authors:  E D Louis; J Benito-León; S Vega-Quiroga; F Bermejo-Pareja
Journal:  Eur J Neurol       Date:  2010-10       Impact factor: 6.089

8.  The gait disorder of advanced essential tremor.

Authors:  H Stolze; G Petersen; J Raethjen; R Wenzelburger; G Deuschl
Journal:  Brain       Date:  2001-11       Impact factor: 13.501

9.  Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases.

Authors:  Elan D Louis; Angus Agnew; Arthur Gillman; Marina Gerbin; Amanda S Viner
Journal:  J Neurol Neurosurg Psychiatry       Date:  2011-03-24       Impact factor: 10.154

10.  Functional correlates of lower cognitive test scores in essential tremor.

Authors:  Elan D Louis
Journal:  Mov Disord       Date:  2010-03-15       Impact factor: 10.338

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  17 in total

Review 1.  Review on clinical update of essential tremor.

Authors:  Wei Chunling; Xiao Zheng
Journal:  Neurol Sci       Date:  2016-01-09       Impact factor: 3.307

2.  Disorders of balance and gait in essential tremor are associated with midline tremor and age.

Authors:  Martina Hoskovcová; Olga Ulmanová; Otakar Sprdlík; Tomáš Sieger; Jana Nováková; Robert Jech; Evžen Růžička
Journal:  Cerebellum       Date:  2013-02       Impact factor: 3.847

3.  Facial emotion recognition is inversely correlated with tremor severity in essential tremor.

Authors:  Nicolas Auzou; Alexandra Foubert-Samier; Sandrine Dupouy; Wassilios G Meissner
Journal:  J Neural Transm (Vienna)       Date:  2013-11-01       Impact factor: 3.575

Review 4.  Essential Tremor Within the Broader Context of Other Forms of Cerebellar Degeneration.

Authors:  Elan D Louis; Phyllis L Faust
Journal:  Cerebellum       Date:  2020-12       Impact factor: 3.847

Review 5.  'Essential tremor' or 'the essential tremors': is this one disease or a family of diseases?

Authors:  Elan D Louis
Journal:  Neuroepidemiology       Date:  2013-12-03       Impact factor: 3.282

Review 6.  Essential tremor.

Authors:  Lorraine N Clark; Elan D Louis
Journal:  Handb Clin Neurol       Date:  2018

7.  The balance and gait disorder of essential tremor: what does this mean for patients?

Authors:  David Arkadir; Elan D Louis
Journal:  Ther Adv Neurol Disord       Date:  2013-07       Impact factor: 6.570

8.  Essential tremor is not a neurodegenerative disease.

Authors:  Ali H Rajput; Charles H Adler; Holly A Shill; Alex Rajput
Journal:  Neurodegener Dis Manag       Date:  2012-06

9.  Tremor: clinical phenomenology and assessment techniques.

Authors:  Christopher W Hess; Seth L Pullman
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-06-28

10.  Essential tremor, the cerebellum, and motor timing: towards integrating them into one complex entity.

Authors:  Martin Bareš; Ivica Husárová; Ovidiu V Lungu
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-09-12
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