Literature DB >> 21486694

Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates.

Xiao-Juan Wang1, Hai-Wei Xu, Lin-Lin Guo, Jia-Xin Zheng, Bo Xu, Xiao Guo, Chen-Xin Zheng, Hong-Min Liu.   

Abstract

Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC(50) <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21486694     DOI： 10.1016/j.bmcl.2011.03.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Molecular diversity of phenothiazines: design and synthesis of phenothiazine-dithiocarbamate hybrids as potential cell cycle blockers.

Authors:  Dong-Jun Fu; Ruo-Han Zhao; Jia-Huan Li; Jia-Jia Yang; Ruo-Wang Mao; Bo-Wen Wu; Ping Li; Xiao-Lin Zi; Qing-Qing Zhang; Hui-Jie Cai; Sai-Yang Zhang; Yan-Bing Zhang; Hong-Min Liu
Journal:  Mol Divers       Date:  2017-08-07       Impact factor: 2.943

2.  Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

Authors:  Dong-Jun Fu; Li Zhang; Jian Song; Ruo-Wang Mao; Ruo-Han Zhao; Ying-Chao Liu; Yu-Hui Hou; Jia-Huan Li; Jia-Jia Yang; Cheng-Yun Jin; Ping Li; Xiao-Lin Zi; Hong-Min Liu; Sai-Yang Zhang; Yan-Bing Zhang
Journal:  Eur J Med Chem       Date:  2016-12-14       Impact factor: 6.514

3.  7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

Authors:  Michael P D'Erasmo; William B Smith; Alberto Munoz; Poornima Mohandas; Andrew S Au; Jason J Marineau; Luis E N Quadri; James E Bradner; Ryan P Murelli
Journal:  Bioorg Med Chem Lett       Date:  2014-06-12       Impact factor: 2.823

4.  Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.

Authors:  Yi-Chao Zheng; Ying-Chao Duan; Jin-Lian Ma; Rui-Min Xu; Xiaolin Zi; Wen-Lei Lv; Meng-Meng Wang; Xian-Wei Ye; Shun Zhu; David Mobley; Yan-Yan Zhu; Jun-Wei Wang; Jin-Feng Li; Zhi-Ru Wang; Wen Zhao; Hong-Min Liu
Journal:  J Med Chem       Date:  2013-11-01       Impact factor: 7.446

5.  Copper Ion Attenuated the Antiproliferative Activity of Di-2-pyridylhydrazone Dithiocarbamate Derivative; However, There Was a Lack of Correlation between ROS Generation and Antiproliferative Activity.

Authors:  Tingting Wang; Yun Fu; Tengfei Huang; Youxun Liu; Meihao Wu; Yanbin Yuan; Shaoshan Li; Changzheng Li
Journal:  Molecules       Date:  2016-08-20       Impact factor: 4.411
  5 in total

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