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Literature DB >> 21486668

Insulin resistance influences central opioid activity in polycystic ovary syndrome.

Alison Berent-Spillson¹, Tiffany Love, Rodica Pop-Busui, MaryFran Sowers, Carol C Persad, Kathryn P Pennington, Aimee D Eyvazaddeh, Vasantha Padmanabhan, Jon-Kar Zubieta, Yolanda R Smith.

Abstract

This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21486668 PMCID： PMC3124614 DOI： 10.1016/j.fertnstert.2011.03.031

Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329

50 in total

Review 1. Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions.

Authors: Kristen Farrell; Michael H Antoni
Journal: Fertil Steril Date: 2010-05-14 Impact factor: 7.329

2. Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women.

Authors: Yolanda R Smith; Christian S Stohler; Thomas E Nichols; Joshua A Bueller; Robert A Koeppe; Jon-Kar Zubieta
Journal: J Neurosci Date: 2006-05-24 Impact factor: 6.167

3. Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome.

Authors: R J Norman; L Masters; C R Milner; J X Wang; M J Davies
Journal: Hum Reprod Date: 2001-09 Impact factor: 6.918

4. Regional mu opioid receptor regulation of sensory and affective dimensions of pain.

Authors: J K Zubieta; Y R Smith; J A Bueller; Y Xu; M R Kilbourn; D M Jewett; C R Meyer; R A Koeppe; C S Stohler
Journal: Science Date: 2001-07-13 Impact factor: 47.728

5. Difference in dietary intake between women with polycystic ovary syndrome and healthy controls.

Authors: Crystal C Douglas; Leigh E Norris; Robert A Oster; Betty E Darnell; Ricardo Azziz; Barbara A Gower
Journal: Fertil Steril Date: 2006-06-08 Impact factor: 7.329

6. A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC.

Authors: D M Jewett
Journal: Nucl Med Biol Date: 2001-08 Impact factor: 2.408

7. Prevalence of psychiatric disorders in patients with polycystic ovary syndrome.

Authors: Arabella Rassi; André Barciela Veras; Moema dos Reis; Daniele Lauriano Pastore; Leandro Marchetti Bruno; Ricardo Vasconcellos Bruno; Márcio Augusto Pinto de Ávila; Antonio E Nardi
Journal: Compr Psychiatry Date: 2010-03-29 Impact factor: 3.735

Insulin resistance influences central opioid activity in polycystic ovary syndrome.

Review 1. Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions.

2. Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women.

3. Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome.

4. Regional mu opioid receptor regulation of sensory and affective dimensions of pain.

5. Difference in dietary intake between women with polycystic ovary syndrome and healthy controls.

6. A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC.

7. Prevalence of psychiatric disorders in patients with polycystic ovary syndrome.

8. Normalization of hyperinsulinemia by chronic opioid receptor blockade in hyperandrogenemic women.

Review 9. The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome.

Review 10. Role of opioid antagonists in the treatment of women with glucoregulation abnormalities.

Review 1. Corticotropin releasing hormone and imaging, rethinking the stress axis.

2. Metabolic and hormone influences on emotion processing during menopause.

3. Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study.