Literature DB >> 21486529

Review of pharmaceutical applications of N-methyl-2-pyrrolidone.

Abolghasem Jouyban1, Mohammad A A Fakhree, Ali Shayanfar.   

Abstract

N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.

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Year:  2010        PMID： 21486529     DOI： 10.18433/j3p306

Source DB:  PubMed          Journal:  J Pharm Pharm Sci        ISSN： 1482-1826            Impact factor:   2.327


  18 in total

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8.  The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis.

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9.  Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury.

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10.  Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Authors:  Martina Kovarova; S Rahima Benhabbour; Ivana Massud; Rae Ann Spagnuolo; Brianna Skinner; Caroline E Baker; Craig Sykes; Katie R Mollan; Angela D M Kashuba; J Gerardo García-Lerma; Russell J Mumper; J Victor Garcia
Journal:  Nat Commun       Date:  2018-10-08       Impact factor: 14.919
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