Literature DB >> 21486043

Multicomponent synthesis of fused benzimidazolopiperazines.

Laurent El Kaïm1, Laurence Grimaud, Srinivas Reddy Purumandla.   

Abstract

We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.

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Year:  2011        PMID： 21486043     DOI： 10.1021/jo200397m

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

Review 1.  Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.

Authors:  Simpal Kumari; Dharma Kishore; Sarvesh Paliwal; Rajani Chauhan; Jaya Dwivedi; Aakanksha Mishra
Journal:  Mol Divers       Date:  2015-06-09       Impact factor: 2.943

2.  Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines.

Authors:  Zhigang Xu; Arthur Y Shaw; Justin Dietrich; Alexandra P Cappelli; Gary Nichol; Christopher Hulme
Journal:  Mol Divers       Date:  2012-01-12       Impact factor: 2.943

3.  Regioselective addition of Grignard reagents to N-acylpyrazinium salts: synthesis of substituted 1,2-dihydropyrazines and Δ5-2-oxopiperazines.

Authors:  Valentine R St Hilaire; William E Hopkins; Yenteeo S Miller; Srinivasa R Dandepally; Alfred L Williams
Journal:  Beilstein J Org Chem       Date:  2019-01-08       Impact factor: 2.883
  3 in total

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