Polyelectrolyte stabilized antimalarial nanosuspension using factorial design approach.

The use of most of the antimalarials like pyrimethamine is restricted owing to their poor solubility and low bioavailability problems. In this study the combined effects of polyelectrolyte stabilizers on effective particle size reduction and stability of antimalarial nanosuspension using a factorial design approach. Stable nanosuspension with submicron sized particles were obtained by combining non-ionic polyelectrolyte with either of the ionic polyelectrolytes tested. Factorial design was found to be a sound approach to analyze the effects of stabilizers on preparation of pyrimethamine nanosuspension.