Literature DB >> 21485823

Titanium dioxide nanoparticles induce oxidative stress-mediated apoptosis in human keratinocyte cells.

Ritesh K Shukla1, Ashutosh Kumar, Alok K Pandey, Shashi S Singh, Alok Dhawan.   

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) are the most commonly used metal oxide NPs in various industrial and commercial products. The present study has demonstrated a significant cellular uptake of TiO2 NPs in the human keratinocyte cells (HaCaT) using transmission electron microscopy and flow cytometry. The data exhibited a significant (p < 0.05) concentration dependent decrease in cell viability and glutathione with concomitant increase in lipid peroxidation and reactive oxygen species. The increased oxidative stress further leads to apoptosis after 48 h of exposure. Our study demonstrates oxidative stress mediated apoptosis in human keratinocyte cells exposed to TiO2 NPs.

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Year:  2011        PMID： 21485823     DOI： 10.1166/jbn.2011.1221

Source DB:  PubMed          Journal:  J Biomed Nanotechnol        ISSN： 1550-7033            Impact factor:   4.099


  21 in total

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Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

2.  Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damage.

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Journal:  Toxicol Appl Pharmacol       Date:  2012-06-13       Impact factor: 4.219

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Journal:  Mater Sci Eng C Mater Biol Appl       Date:  2017-04-26       Impact factor: 7.328

4.  Microwave-irradiation-assisted hybrid chemical approach for titanium dioxide nanoparticle synthesis: microbial and cytotoxicological evaluation.

Authors:  Shivendu Ranjan; Nandita Dasgupta; Bhavapriya Rajendran; Ganesh S Avadhani; Chidambaram Ramalingam; Ashutosh Kumar
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Journal:  Environ Sci Pollut Res Int       Date:  2019-10-06       Impact factor: 4.223

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7.  Foodborne TiO2 Nanoparticles Induced More Severe Hepatotoxicity in Fructose-Induced Metabolic Syndrome Mice via Exacerbating Oxidative Stress-Mediated Intestinal Barrier Damage.

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Journal:  Foods       Date:  2021-04-30

8.  Immunostimulatory effects of silica nanoparticles in human monocytes.

Authors:  Eun-Jeoung Yang; In-Hong Choi
Journal:  Immune Netw       Date:  2013-06-30       Impact factor: 6.303

9.  Molecular mechanism of mice gastric oxidative damage induced by nanoparticulate titanium dioxide.

Authors:  Jianhui Ji; Yingjun Zhou; Fashui Hong; Yuguan Ze; Dongxue Fan; Xingxiang Zhang
Journal:  Toxicol Res (Camb)       Date:  2021-01-05       Impact factor: 3.524

10.  ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes.

Authors:  Jieting Wang; Xiaobei Deng; Fang Zhang; Deliang Chen; Wenjun Ding
Journal:  Nanoscale Res Lett       Date:  2014-03-13       Impact factor: 4.703
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