Literature DB >> 21485798

Design and development of Amphotericin B bearing polycaprolactone microparticles for macrophage targeting.

Pankaj Singh1, Amit Gupta, Anil Jaiswal, Anuradha Dube, Saurabh Mishra, Manish K Chaurasia.   

Abstract

Antileishmanial efficacy of Amphotericin B bearing polycaprolactone (PCL) microparticles was investigated. The microparticles were prepared, optimized and subjected to in vitro characterization for shape (spherically structured), particle size (9.83 +/- 1.12 microm), entrapment efficiency (43.54 +/- 3.98%) and in vitro drug release. The study revealed that PCL microparticles bearing Amphotericin B can be effectively used to target leishmanial parasites residing in macrophages.

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Year:  2011        PMID： 21485798     DOI： 10.1166/jbn.2011.1196

Source DB:  PubMed          Journal:  J Biomed Nanotechnol        ISSN： 1550-7033            Impact factor:   4.099


  4 in total

1.  Bioinspired Calcium Phosphate Nanoparticles Featuring as Efficient Carrier and Prompter for Macrophage Intervention in Experimental Leishmaniasis.

Authors:  Mohini Chaurasia; Pankaj K Singh; Anil K Jaiswal; Animesh Kumar; Vivek K Pawar; Anuradha Dube; Sarvesh K Paliwal; Manish K Chourasia
Journal:  Pharm Res       Date:  2016-07-11       Impact factor: 4.200

2.  Fabrication of 3-O-sn-Phosphatidyl-L-serine Anchored PLGA Nanoparticle Bearing Amphotericin B for Macrophage Targeting.

Authors:  Pankaj K Singh; Anil K Jaiswal; Vivek K Pawar; Kavit Raval; Animesh Kumar; Himangsu K Bora; Anuradha Dube; Manish K Chourasia
Journal:  Pharm Res       Date:  2018-02-09       Impact factor: 4.200

3.  Arginine-α, β-dehydrophenylalanine Dipeptide Nanoparticles for pH-Responsive Drug Delivery.

Authors:  Pankaj Kumar Singh; Sonika Chibh; Taru Dube; Virander Singh Chauhan; Jiban Jyoti Panda
Journal:  Pharm Res       Date:  2018-01-16       Impact factor: 4.200

4.  PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone.

Authors:  Giovanna Giacalone; Nicolas Tsapis; Ludivine Mousnier; Hélène Chacun; Elias Fattal
Journal:  Materials (Basel)       Date:  2018-09-27       Impact factor: 3.623
  4 in total

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