Literature DB >> 2148476

Tissue specificity in expression and alternative RNA splicing of human phosphofructokinase-M and -L genes.

H Nakajima1, N Kono, T Yamasaki, T Hamaguchi, K Hotta, M Kuwajima, T Noguchi, T Tanaka, S Tarui.   

Abstract

Mode of the expression of phosphofructokinase (PFK) -M and -L genes was examined in various human tissues including muscle, placenta, liver, kidney, pancreas, stomach and reticulocytes. The gross level of mRNA expression of PFK-M and -L genes was estimated by Northern analysis. Polymerase chain reaction was used to detect mRNA expressed at low levels in these tissues. Tissue-specific expression of alternatively spliced PFK-M gene transcripts was also determined by polymerase chain reaction. The results indicated that alternative splicing of PFK-M gene transcripts was controlled in a tissue-specific manner.

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Year:  1990        PMID： 2148476     DOI： 10.1016/s0006-291x(05)80931-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Alteration of the levels of the M-type 6-phosphofructo-1-kinase mRNA isoforms during neonatal maturation of heart, brain and muscle.

Authors:  Y Mhaskar; G Armour; G Dunaway
Journal:  Mol Cell Biochem       Date:  2000-11       Impact factor: 3.396

2.  Glycogenosis type VII (Tarui disease) in a Swedish family: two novel mutations in muscle phosphofructokinase gene (PFK-M) resulting in intron retentions.

Authors:  R C Nichols; O Rudolphi; B Ek; R Exelbert; P H Plotz; N Raben
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

3.  A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21.

Authors:  J Kuromitsu; H Yamashita; H Kataoka; T Takahara; M Muramatsu; T Sekine; N Okamoto; Y Furuichi; Y Hayashizaki
Journal:  Mol Cell Biol       Date:  1997-02       Impact factor: 4.272

4.  Novel clustering of Sp1 transcription factor binding sites at the transcription initiation site of the human muscle phosphofructokinase P1 promoter.

Authors:  J L Johnson; A McLachlan
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

5.  Expression of mouse phosphofructokinase-M gene alternative transcripts: evidence for the conserved two-promoter system.

Authors:  H Nakajima; T Noguchi; T Hamaguchi; K Tomita; T Hanafusa; N Kono; T Tanaka; M Kuwajima; Y Matsuzawa
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

6.  Common mutations in the phosphofructokinase-M gene in Ashkenazi Jewish patients with glycogenesis VII--and their population frequency.

Authors:  J B Sherman; N Raben; C Nicastri; Z Argov; H Nakajima; E M Adams; C M Eng; T M Cowan; P H Plotz
Journal:  Am J Hum Genet       Date:  1994-08       Impact factor: 11.025

7.  Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.

Authors:  N Raben; R Exelbert; R Spiegel; J B Sherman; H Nakajima; P Plotz; J Heinisch
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

8.  Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency.

Authors:  S Tsujino; S Servidei; P Tonin; S Shanske; G Azan; S DiMauro
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

9.  McArdle's disease. The unsolved mystery of the reappearing enzyme.

Authors:  A Martinuzzi; G Schievano; A Nascimbeni; M Fanin
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307
  9 in total

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