PURPOSE: Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. METHODS:A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. RESULTS: There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. CONCLUSIONS: Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.
RCT Entities:
PURPOSE: Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obesewomen with polycystic ovary syndrome. METHODS: A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. RESULTS: There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. CONCLUSIONS: Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.
Authors: D S Kiddy; D Hamilton-Fairley; A Bush; F Short; V Anyaoku; M J Reed; S Franks Journal: Clin Endocrinol (Oxf) Date: 1992-01 Impact factor: 3.478
Authors: R Pasquali; D Antenucci; F Casimirri; S Venturoli; R Paradisi; R Fabbri; V Balestra; N Melchionda; L Barbara Journal: J Clin Endocrinol Metab Date: 1989-01 Impact factor: 5.958
Authors: Emily S Jungheim; Jennifer L Travieso; Kenneth R Carson; Kelle H Moley Journal: Obstet Gynecol Clin North Am Date: 2012-12 Impact factor: 2.844