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Literature DB >> 21483450

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

Nan Chen, Oliver Rinner, Dominika Czernik, Katarzyna J Nytko, Dan Zheng, Daniel P Stiehl, Nicola Zamboni, Matthias Gstaiger, Christian Frei.

Abstract

Entities: Chemical Disease Gene

Mesh：

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Year: 2011 PMID： 21483450 PMCID： PMC3337712 DOI： 10.1038/cr.2011.66

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

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10 in total

1. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.

Authors: Norma Masson; Rebecca J Appelhoff; Jason R Tuckerman; Ya-Min Tian; Hans Demol; Magda Puype; Joel Vandekerckhove; Peter J Ratcliffe; Christopher W Pugh
Journal: FEBS Lett Date: 2004-07-16 Impact factor: 4.124

2. Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.

Authors: Katarzyna J Nytko; Patrick Spielmann; Gieri Camenisch; Roland H Wenger; Daniel P Stiehl
Journal: Antioxid Redox Signal Date: 2007-09 Impact factor: 8.401

3. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Authors: Jill D Dombrauckas; Bernard D Santarsiero; Andrew D Mesecar
Journal: Biochemistry Date: 2005-07-12 Impact factor: 3.162

Review 4. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.

Authors: Sybille Mazurek
Journal: Int J Biochem Cell Biol Date: 2010-02-13 Impact factor: 5.085

Review 5. Why do cancers have high aerobic glycolysis?

Authors: Robert A Gatenby; Robert J Gillies
Journal: Nat Rev Cancer Date: 2004-11 Impact factor: 60.716

6. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Authors: Edurne Berra; Emmanuel Benizri; Amandine Ginouvès; Véronique Volmat; Danièle Roux; Jacques Pouysségur
Journal: EMBO J Date: 2003-08-15 Impact factor: 11.598

7. Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.

Authors: Anne Couvelard; Lydia Deschamps; Vinciane Rebours; Alain Sauvanet; Kevin Gatter; Francesco Pezzella; Philippe Ruszniewski; Pierre Bedossa
Journal: Clin Cancer Res Date: 2008-10-15 Impact factor: 12.531

8. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Authors: Heather R Christofk; Matthew G Vander Heiden; Marian H Harris; Arvind Ramanathan; Robert E Gerszten; Ru Wei; Mark D Fleming; Stuart L Schreiber; Lewis C Cantley
Journal: Nature Date: 2008-03-13 Impact factor: 49.962

Review 9. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Authors: William G Kaelin; Peter J Ratcliffe
Journal: Mol Cell Date: 2008-05-23 Impact factor: 17.970

10. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth.

Authors: Christian Frei; Bruce A Edgar
Journal: Dev Cell Date: 2004-02 Impact factor: 12.270

10 in total

14 in total

1. Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.

Authors: Sunil Kumar; Ashok Kumar Patel
Journal: Mol Biotechnol Date: 2020-02 Impact factor: 2.695

Review 2. Endothelial cell metabolism in health and disease: impact of hypoxia.

Authors: Brian W Wong; Elke Marsch; Lucas Treps; Myriam Baes; Peter Carmeliet
Journal: EMBO J Date: 2017-06-21 Impact factor: 11.598

Review 3. The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Authors: Catherine J Libby; Jonathan McConathy; Victor Darley-Usmar; Anita B Hjelmeland
Journal: Cancer Res Date: 2019-10-01 Impact factor: 12.701

Review 4. The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.

Authors: Silvia Strocchi; Francesca Reggiani; Giulia Gobbi; Alessia Ciarrocchi; Valentina Sancisi
Journal: Oncogene Date: 2022-06-15 Impact factor: 8.756

Review 5. A critical review of the role of M₂PYK in the Warburg effect.

Authors: Robert A Harris; Aron W Fenton
Journal: Biochim Biophys Acta Rev Cancer Date: 2019-01-29 Impact factor: 10.680

6. Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase.

Authors: Adam J Case; James J Mezhir; Brianne R O'Leary; Jennifer E Hrabe; Frederick E Domann
Journal: Redox Rep Date: 2012 Impact factor: 4.412

7. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells.

Authors: Weibo Luo; Gregg L Semenza
Journal: Oncotarget Date: 2011-07

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

1. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.

2. Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.

3. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Review 4. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.

Review 5. Why do cancers have high aerobic glycolysis?

6. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

7. Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.

8. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Review 9. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

10. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth.

1. Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.

Review 2. Endothelial cell metabolism in health and disease: impact of hypoxia.

Review 3. The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Review 4. The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.

Review 5. A critical review of the role of M₂PYK in the Warburg effect.

6. Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase.

7. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells.

8. Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein.

9. Anomalies in network bridges involved in bile Acid metabolism predict outcomes of colorectal cancer patients.

10. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.

Review 4. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.

Review 5. Why do cancers have high aerobic glycolysis?

Review 9. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Review 2. Endothelial cell metabolism in health and disease: impact of hypoxia.

Review 3. The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Review 4. The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.

Review 5. A critical review of the role of M2PYK in the Warburg effect.

Review 5. A critical review of the role of M₂PYK in the Warburg effect.