Literature DB >> 21482108

Development of a highly selective fluorescence probe for alkaline phosphatase.

Mitsuyasu Kawaguchi1, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tetsuo Nagano.   

Abstract

We have developed the first highly selective fluorescence probe for alkaline phosphatase (ALP), TG-mPhos. This probe shows selectivity for ALP over protein tyrosine phosphatase and protein serine/threonine phosphatase. Our previously developed TG-Phos, which has a phenolic phosphate linkage in place of the alcoholic phosphate linkage of TG-mPhos, lacks this selectivity. TG-mPhos should enable precise fluorescence imaging of ALP activity in biological applications.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21482108     DOI： 10.1016/j.bmcl.2011.03.070

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Interrogating Protein Phosphatases with Chemical Activity Probes.

Authors:  Garrett R Casey; Cliff I Stains
Journal:  Chemistry       Date:  2018-03-08       Impact factor: 5.236

2.  A label-free and modification-free ratiometric electrochemical strategy for enhanced natural enzyme detection using a bare electrode and nanozymes system.

Authors:  Honghong Rao; Jianying Li; Mingyue Luo; Kehui Zhang; Hao Gou; Haixia Liu; Zhonghua Xue
Journal:  Anal Bioanal Chem       Date:  2022-02-01       Impact factor: 4.142

3.  Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples.

Authors:  Shingo Sakamoto; Toru Komatsu; Rikiya Watanabe; Yi Zhang; Taiki Inoue; Mitsuyasu Kawaguchi; Hidehiko Nakagawa; Takaaki Ueno; Takuji Okusaka; Kazufumi Honda; Hiroyuki Noji; Yasuteru Urano
Journal:  Sci Adv       Date:  2020-03-11       Impact factor: 14.136
  3 in total

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