OBJECTIVE: Adipose-tissue derived adiponectin has gained a lot of interest as a marker of metabolic syndrome (MetS) and cardiovascular risk. The objective of this study was to assess whether adiponectin levels in young adults predict the incidence of MetS after 6-year follow-up. To gain insight on the interrelations between MetS, adiponectin and cardiovascular risk, we also examined the associations of adiponectin and carotid atherosclerosis according to MetS status. METHODS: This analysis was part of a population-based, longitudinal cohort study conducted among 1693 Cardiovascular Risk in Young Finns Study individuals (age 31.9 ± 4.9 years in 2001) participating in follow-ups in 2001 and 2007. RESULTS: In a multivariable model adjusted for age, sex, MetS components, LDL-cholesterol, CRP, insulin, leptin, smoking and family history of coronary disease, 1-unit increase in baseline adiponectin levels was associated with reduced odds (odds ratio [OR]=0.94, 95% CI 0.89-0.99, P=0.04) of incident MetS. Of the MetS components, adiponectin levels were inversely associated with the incidence of hyperglycemia in multivariable analyses (OR=0.94 (0.90-0.99), P=0.04). When studying the adiponectin×MetS interaction on IMT, we observed a significant interaction when examining IMT in 2001 (r=-0.11 (MetS(-)) vs. r=-0.17 (MetS(+)), P for interaction 0.047) and IMT in 2007 (r=-0.12 (MetS(-)) vs. r=-0.21 (MetS(+)), P for interaction 0.005), suggesting the inverse association between adiponectin and IMT is stronger among those with MetS. CONCLUSIONS: Among young adults, high adiponectin levels were associated with decreased incidence of MetS. Moreover, our data suggest that individuals with MetS are more vulnerable to the proatherogenic effects of low adiponectin levels.
OBJECTIVE: Adipose-tissue derived adiponectin has gained a lot of interest as a marker of metabolic syndrome (MetS) and cardiovascular risk. The objective of this study was to assess whether adiponectin levels in young adults predict the incidence of MetS after 6-year follow-up. To gain insight on the interrelations between MetS, adiponectin and cardiovascular risk, we also examined the associations of adiponectin and carotid atherosclerosis according to MetS status. METHODS: This analysis was part of a population-based, longitudinal cohort study conducted among 1693 Cardiovascular Risk in Young Finns Study individuals (age 31.9 ± 4.9 years in 2001) participating in follow-ups in 2001 and 2007. RESULTS: In a multivariable model adjusted for age, sex, MetS components, LDL-cholesterol, CRP, insulin, leptin, smoking and family history of coronary disease, 1-unit increase in baseline adiponectin levels was associated with reduced odds (odds ratio [OR]=0.94, 95% CI 0.89-0.99, P=0.04) of incident MetS. Of the MetS components, adiponectin levels were inversely associated with the incidence of hyperglycemia in multivariable analyses (OR=0.94 (0.90-0.99), P=0.04). When studying the adiponectin×MetS interaction on IMT, we observed a significant interaction when examining IMT in 2001 (r=-0.11 (MetS(-)) vs. r=-0.17 (MetS(+)), P for interaction 0.047) and IMT in 2007 (r=-0.12 (MetS(-)) vs. r=-0.21 (MetS(+)), P for interaction 0.005), suggesting the inverse association between adiponectin and IMT is stronger among those with MetS. CONCLUSIONS: Among young adults, high adiponectin levels were associated with decreased incidence of MetS. Moreover, our data suggest that individuals with MetS are more vulnerable to the proatherogenic effects of low adiponectin levels.
Authors: Angelo Scuteri; Pedro G Cunha; E Agabiti Rosei; Jolita Badariere; Sofie Bekaert; John R Cockcroft; Jorge Cotter; Francesco Cucca; Marc L De Buyzere; Tim De Meyer; Luigi Ferrucci; Osca Franco; Nichola Gale; Thierry C Gillebert; A Hofman; Michel Langlois; Aleksandras Laucevicius; Stephane Laurent; Francesco U S Mattace Raso; Cristopher H Morrell; Maria Lorenza Muiesan; Margaret M Munnery; Rokas Navickas; Pedro Oliveira; Marco Orru'; Maria Grazia Pilia; Ernst R Rietzschel; Ligita Ryliskyte; Massimo Salvetti; David Schlessinger; Nuno Sousa; Christodoulos Stefanadis; James Strait; Caroline Van Daele; Isabel Villa; Charalambos Vlachopoulos; Jacqueline Witteman; Panagiotis Xaplanteris; Peter Nilsson; Edward G Lakatta Journal: Atherosclerosis Date: 2014-01-30 Impact factor: 5.162
Authors: Elaine Hui; Aimin Xu; Wing-Sun Chow; Paul C H Lee; Carol H Y Fong; Stephen C W Cheung; Hung Fat Tse; Ming-Tak Chau; Bernard M Y Cheung; Karen S L Lam Journal: Metab Syndr Relat Disord Date: 2014-09-11 Impact factor: 1.894
Authors: Marion Flechtner-Mors; Samuel N George; Suemeyra Oeztuerk; Mark M Haenle; Wolfgang Koenig; Armin Imhof; Bernhard O Boehm; Tilmann Graeter; Richard A Mason; Wolfgang Kratzer; Atilla S Akinli Journal: BMC Res Notes Date: 2014-04-03