CONCLUSIONS: Altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (SCC) independent of human papilloma virus (HPV) infection may lead to tumor progression. OBJECTIVES: Integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. HPV is significantly associated with tonsillar SCC. We sought to determine the expression of claudin-1, claudin-7, and tricellulin in HPV-infected and HPV-free tonsillar SCC. METHODS: Twenty-eight tonsillar SCCs were studied by immunohistochemical analysis and real-time reverse transcription polymerase chain reaction with in situ hybridization analysis. RESULTS: Compared with normal tissues, claudin-1 was strongly expressed, whereas claudin-7 and tricellulin were weakly expressed or were absent in primary SCC and metastatic lymph nodes. Claudin-7 and tricellulin were markedly reduced at all stages of tumor development. In situ hybridization analysis showed no correlation between HPV infection and altered expression of the tight junction proteins.
CONCLUSIONS: Altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (SCC) independent of humanpapilloma virus (HPV) infection may lead to tumor progression. OBJECTIVES: Integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. HPV is significantly associated with tonsillar SCC. We sought to determine the expression of claudin-1, claudin-7, and tricellulin in HPV-infected and HPV-free tonsillar SCC. METHODS: Twenty-eight tonsillar SCCs were studied by immunohistochemical analysis and real-time reverse transcription polymerase chain reaction with in situ hybridization analysis. RESULTS: Compared with normal tissues, claudin-1 was strongly expressed, whereas claudin-7 and tricellulin were weakly expressed or were absent in primary SCC and metastatic lymph nodes. Claudin-7 and tricellulin were markedly reduced at all stages of tumor development. In situ hybridization analysis showed no correlation between HPV infection and altered expression of the tight junction proteins.
Authors: Aron Somorácz; Anna Korompay; Péter Törzsök; Attila Patonai; Boglárka Erdélyi-Belle; Gábor Lotz; Zsuzsa Schaff; András Kiss Journal: Pathol Oncol Res Date: 2014-03-21 Impact factor: 3.201
Authors: Shiqi Zhang; Tao Zeng; Bin Hu; Yu-Hang Zhang; Kaiyan Feng; Lei Chen; Zhibin Niu; Jianhao Li; Tao Huang; Yu-Dong Cai Journal: Front Bioeng Biotechnol Date: 2020-05-26