| Literature DB >> 21480411 |
M Zhao1, S T Lau, P S Leung, C T Che, Z X Lin.
Abstract
Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines. A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, yadanzioside A, yadanzioside G, javanicoside C and bruceantinoside A. Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 µm and 0.10 µm on PANC-1 and SW1990 cell lines, respectively. This is the first report on the antipancreatic adenocarcinoma activity of brusatol.Entities:
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Year: 2011 PMID： 21480411 DOI： 10.1002/ptr.3477
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878