| Literature DB >> 21479750 |
Ira Soppela1, Sari Airaksinen, Juha Hatara, Heikki Räikkönen, Osmo Antikainen, Jouko Yliruusi, Niklas Sandler.
Abstract
The present study introduces a new three-dimensional (3D) surface image analysis technique in which white light illumination from different incident angles is used to create 3D surfaces with a photometric approach. The three-dimensional features of the surface images created are then used in the characterization of particle size distributions of granules. This surface image analysis method is compared to sieve analysis and a particle sizing method based on spatial filtering technique with nearly 30 granule batches. The aim is also to evaluate the technique in flowability screening of granular materials. Overall, the new 3D imaging approach allows a rapid analysis of large amounts of sample and gives valuable visual information on the granule surfaces in terms of surface roughness and particle shape.Mesh:
Substances:
Year: 2011 PMID: 21479750 PMCID: PMC3134653 DOI: 10.1208/s12249-011-9607-0
Source DB: PubMed Journal: AAPS PharmSciTech ISSN: 1530-9932 Impact factor: 3.246