| Literature DB >> 2147975 |
J G Filep1, B Battistini, P Sirois.
Abstract
The possible role of thromboxane (TX) A2 in mediating the bronchopulmonary effect of endothelin (ET) was studied in isolated guinea pig airways (trachea, upper bronchi and parenchyma). ET (1-100 nM) evoked a concentration-dependent contraction of all three tissues. The contractile response was significantly attenuated by pretreatment of the tissues with the specific thromboxane receptor blockers, BM 13177 (10-50 microM) and BM 13505 (1-5 microM). Furthermore, ET caused a dose-dependent TXB2 release from trachea and parenchyma. These findings suggest that the bronchopulmonary action of ET is mediated, in part, by the release of TXA2.Entities:
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Year: 1990 PMID： 2147975 DOI： 10.1016/0024-3205(90)90287-2
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037