PURPOSE: Patients' physiological functions and health-related quality of life (QOL) are useful for planning physical therapy after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but have not been extensively examined prior to transplantation. We investigated whether physiological functions and health-related QOL were reduced in patients before undergoing allo-HSCT. METHODS: All patients (n = 110) who underwent allo-HSCT between May 2007 and April 2010 at Hyogo College of Medicine Hospital were included in this study and evaluated for hand-grip and knee-extensor strength; 6-min walk test (6MWT) and health-related QOL (SF-36) were also used for evaluation. RESULTS: Grip strength, knee-extensor strength, 6MWT, and all eight SF-36 health-related QOL subscale scores significantly decreased in HSCT patients compared to population norms (all, P < 0.01). Health-related QOL is associated with various confounding factors such as fatigue and sex. Loss of physiological function is also associated with confounding factors; one such association was found between skeletal muscle strength and previous HSCT treatment. CONCLUSION: Health-related QOL and loss of physiological function have a variety confounding factors. Patients scheduled for HSCT may have physiological weaknesses prior to transplant, which need to be considered when planning an exercise regimen during and after transplantation.
PURPOSE:Patients' physiological functions and health-related quality of life (QOL) are useful for planning physical therapy after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but have not been extensively examined prior to transplantation. We investigated whether physiological functions and health-related QOL were reduced in patients before undergoing allo-HSCT. METHODS: All patients (n = 110) who underwent allo-HSCT between May 2007 and April 2010 at Hyogo College of Medicine Hospital were included in this study and evaluated for hand-grip and knee-extensor strength; 6-min walk test (6MWT) and health-related QOL (SF-36) were also used for evaluation. RESULTS: Grip strength, knee-extensor strength, 6MWT, and all eight SF-36 health-related QOL subscale scores significantly decreased in HSCT patients compared to population norms (all, P < 0.01). Health-related QOL is associated with various confounding factors such as fatigue and sex. Loss of physiological function is also associated with confounding factors; one such association was found between skeletal muscle strength and previous HSCT treatment. CONCLUSION: Health-related QOL and loss of physiological function have a variety confounding factors. Patients scheduled for HSCT may have physiological weaknesses prior to transplant, which need to be considered when planning an exercise regimen during and after transplantation.
Authors: Frank Sciurba; Gerard J Criner; Shing M Lee; Zab Mohsenifar; David Shade; William Slivka; Robert A Wise Journal: Am J Respir Crit Care Med Date: 2003-02-20 Impact factor: 21.405
Authors: Fernando Dimeo; Stefan Schwartz; Thomas Fietz; Tabata Wanjura; Dieter Böning; Eckhard Thiel Journal: Support Care Cancer Date: 2003-08-26 Impact factor: 3.603
Authors: Gerald M Devins; Kenneth Mah; Hans A Messner; Anargyros Xenocostas; Lise Gauvin; Jeffrey H Lipton Journal: Support Care Cancer Date: 2018-02-08 Impact factor: 3.603
Authors: T Takekiyo; K Dozono; T Mitsuishi; S Nara; K Yoshida; Y Murayama; A Maeda; T Chaen; N Nakano; A Kubota; M Tokunaga; S Takeuchi; Y Takatsuka; A Utsunomiya Journal: Bone Marrow Transplant Date: 2016-03-21 Impact factor: 5.483
Authors: J Wiskemann; R Kuehl; P Dreger; R Schwerdtfeger; G Huber; C M Ulrich; D Jaeger; M Bohus Journal: Bone Marrow Transplant Date: 2013-12-09 Impact factor: 5.483