Literature DB >> 214784

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

J Schlessinger, Y Shechter, P Cuatrecasas, M C Willingham, I Pastan.   

Abstract

Fluorescent derivatives of insulin and epidermal growth factor bound to 3T3 mouse fibroblasts are mobile on the cell surface, with similar diffusion coefficients, D approximately (3--5) x 10(-10) cm2/sec at 23 degrees C. Increasing the temperature to 37 degrees C results in rapid receptor immobilization. The immobilization is attributed to aggregation of hormone-receptor complexes, their internalization, or a combination of both processes.

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Year:  1978        PMID： 214784      PMCID： PMC392961          DOI： 10.1073/pnas.75.11.5353

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  ISOLATION AND BIOLOGICAL EFFECTS OF AN EPIDERMAL GROWTH-STIMULATING PROTEIN.

Authors:  S COHEN
Journal:  Natl Cancer Inst Monogr       Date:  1964-04

2.  Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin.

Authors:  Y Shechter; J Schlessinger; S Jacobs; K J Chang; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

3.  The natural occurrence of insulin receptors in groups on adipocyte plasma membranes as demonstrated with monomeric ferritin-insulin.

Authors:  L Jarett; R M Smith
Journal:  J Supramol Struct       Date:  1977

4.  Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis.

Authors:  R M Pratt; I Pastan
Journal:  Nature       Date:  1978-03-02       Impact factor: 49.962

5.  Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.

Authors:  J Schlessinger; Y Shechter; M C Willingham; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

6.  Lateral transport of a lipid probe and labeled proteins on a cell membrane.

Authors:  J Schlessinger; D Axelrod; D E Koppel; W W Webb; E L Elson
Journal:  Science       Date:  1977-01-21       Impact factor: 47.728

7.  Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts.

Authors:  G Carpenter; K J Lembach; M M Morrison; S Cohen
Journal:  J Biol Chem       Date:  1975-06-10       Impact factor: 5.157

8.  Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

Authors:  I D Goldfine; G J Smith; K Y Wong; A L Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

9.  Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

Authors:  J Orly; M Schramm
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

10.  125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

Authors:  G Carpenter; S Cohen
Journal:  J Cell Biol       Date:  1976-10       Impact factor: 10.539
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  48 in total

1.  A mechanistic role for polypeptide hormone receptor lateral mobility in signal transduction.

Authors:  D A Jans; I Pavo
Journal:  Amino Acids       Date:  1995-06       Impact factor: 3.520

Review 2.  Mechanisms of receptor-mediated transmembrane signalling.

Authors:  M D Hollenberg
Journal:  Experientia       Date:  1986-07-15

3.  Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere.

Authors:  J J Linderman; D A Lauffenburger
Journal:  Biophys J       Date:  1986-08       Impact factor: 4.033

4.  IgG Fc membrane receptor on normal human glomerular visceral epithelial cells.

Authors:  R Mancilla-Jimenez; M D Appay; B Bellon; J Kuhn; J Bariety; P Druet
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

5.  Saccharin and cyclamate inhibit binding of epidermal growth factor.

Authors:  L S Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

Review 6.  Epidermal growth factor receptors.

Authors:  E D Adamson; A R Rees
Journal:  Mol Cell Biochem       Date:  1981-02-11       Impact factor: 3.396

7.  Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor.

Authors:  L S Lee; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

8.  Lateral motion of beta receptors in membranes of cultured liver cells.

Authors:  Y I Henis; M Hekman; E L Elson; E J Helmreich
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

9.  Lateral diffusion of surface immunoglobulin, Thy-1 antigen, and a lipid probe in lymphocyte plasma membranes.

Authors:  P Dragsten; P Henkart; R Blumenthal; J Weinstein; J Schlessinger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

10.  Diffusion-limited forward rate constants in two dimensions. Application to the trapping of cell surface receptors by coated pits.

Authors:  B Goldstein; R Griego; C Wofsy
Journal:  Biophys J       Date:  1984-11       Impact factor: 4.033
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