| Literature DB >> 21477671 |
Jo Erika T Narciso1, Iris Diana C Uy, April B Cabang, Jenina Faye C Chavez, Juan Lorenzo B Pablo, Gisela P Padilla-Concepcion, Eduardo A Padlan.
Abstract
High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between the residues in the contact between the variable domains, and between the framework and the complementarity-determining regions of the antibody. The solvent accessibilities of the residues in the variable domains were also analyzed. The structural information is useful in the engineering of antibodies for therapeutic and other purposes.Mesh：
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Year: 2011 PMID： 21477671 DOI： 10.1016/j.nbt.2011.03.012
Source DB: PubMed Journal: N Biotechnol ISSN： 1871-6784 Impact factor: 5.079