BACKGROUND: Calcific uremic arteriolopathy is an uncommon cutaneous ischemic necrotizing disease, most commonly associated with renal disease and hyperparathyroidism, bearing a high mortality rate. OBJECTIVE AND METHOD: A case of a 57-year-old female renal patient with hyperparathyroidism who was successfully treated with combined paricalcitol and cinacalcet systemically, while autologous growth factors were locally applied, is herein presented. RESULT AND CONCLUSION: The combination of cinacalcet and paricalcitol is a reliable alternative to parathyroidectomy in patients with calcific uremic arteriolopathy and hyperparathyroidism. Meticulous débridement of necrotic tissues is essential and application of autologous growth factors promotes healing.
BACKGROUND:Calcific uremic arteriolopathy is an uncommon cutaneous ischemic necrotizing disease, most commonly associated with renal disease and hyperparathyroidism, bearing a high mortality rate. OBJECTIVE AND METHOD: A case of a 57-year-old female renal patient with hyperparathyroidism who was successfully treated with combined paricalcitol and cinacalcet systemically, while autologous growth factors were locally applied, is herein presented. RESULT AND CONCLUSION: The combination of cinacalcet and paricalcitol is a reliable alternative to parathyroidectomy in patients with calcific uremic arteriolopathy and hyperparathyroidism. Meticulous débridement of necrotic tissues is essential and application of autologous growth factors promotes healing.
Authors: Vincenzo Barbera; Luca Di Lullo; Antonio Gorini; Giovanni Otranto; Fulvio Floccari; Moreno Malaguti; Alberto Santoboni Journal: Case Rep Urol Date: 2013-06-06
Authors: Thomas Welte; Frederic Arnold; Kristin Technau-Hafsi; Elke Neumann-Haefelin; Rika Wobser; Stefan Zschiedrich; Gerd Walz; Albrecht Kramer-Zucker Journal: Transplant Direct Date: 2016-03-17