Literature DB >> 21477436

Thy3 cytology: what to do next?

Raj Lakhani1, Thomas Rourke, Anthony Jefferis, Louise Perry, Sabour Ghiacy, Stephen Wood.   

Abstract

INTRODUCTION: Cytological analysis of thyroid fine needle aspiration (FNA) is aided by the 'Thy' classification. However, there is often confusion surrounding the management of patients with a Thy3 classification. A subdivision of Thy3 has been created to help reduce this dilemma but its use within the UK appears to by infrequent. This paper analyses the management of patients with Thy3 cytology from FNA of a thyroid nodule in a UK case series and reviews the relevant literature. It also describes the results of a survey of selected UK ENT departments on the use of the Thy3 classification and its subdivisions. PATIENTS AND METHODS: A retrospective analysis of a case series of patients was undertaken. In addition, a telephone survey of local/regional pathology departments was conducted to assess the utilisation of the Thy classification and to assess the awareness and usage of the Thy3 subdivisions.
RESULTS: A total of 39 Thy3 results (11 males, 28 females) were identified from 2007 to 2009. Of these, 24 patients went on to have surgery, 8 had a further FNA, 2 had a Tru-cut biopsy and 5 were lost to follow-up. Eleven (28.2%) patients were subsequently diagnosed with a thyroid malignancy. The survey identified that none of the departments had adopted the Thy3 subclassifications and only 40% were aware of them.
CONCLUSIONS: Thy3 results from thyroid FNA have a significant risk of malignancy but there remains confusion surrounding their management. This district general hospital has adopted and recommends the use of the Thy3 (i) and Thy3 (ii) subdivisions in order to assist decision-making and avoid delays in treatment or unnecessary surgery.

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Year:  2011        PMID: 21477436      PMCID: PMC3291140          DOI: 10.1308/147870811X565232

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  14 in total

1.  Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.

Authors:  David S Cooper; Gerard M Doherty; Bryan R Haugen; Richard T Kloos; Stephanie L Lee; Susan J Mandel; Ernest L Mazzaferri; Bryan McIver; Steven I Sherman; R Michael Tuttle
Journal:  Thyroid       Date:  2006-02       Impact factor: 6.568

2.  Fine-needle aspiration biopsies in the management of indeterminate follicular and Hurthle cell thyroid lesions.

Authors:  Tamara Mijović; Louise Rochon; Olguta Gologan; Michael P Hier; Martin J Black; Jonathan Young; Richard J Payne
Journal:  Otolaryngol Head Neck Surg       Date:  2009-03-12       Impact factor: 3.497

Review 3.  Investigating the thyroid nodule.

Authors:  H M Mehanna; A Jain; R P Morton; J Watkinson; A Shaha
Journal:  BMJ       Date:  2009-03-13

Review 4.  Thyroid aspiration cytology: current status.

Authors:  Lester J Layfield; Edmund S Cibas; Hossein Gharib; Susan J Mandel
Journal:  CA Cancer J Clin       Date:  2009 Mar-Apr       Impact factor: 508.702

5.  The indeterminate thyroid fine-needle aspiration: experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.

Authors:  Ritu Nayar; Marina Ivanovic
Journal:  Cancer       Date:  2009-06-25       Impact factor: 6.860

6.  Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.

Authors:  Zubair W Baloch; Virginia A LiVolsi; Syl L Asa; Juan Rosai; Maria J Merino; Gregory Randolph; Philippe Vielh; Richard M DeMay; Mary K Sidawy; William J Frable
Journal:  Diagn Cytopathol       Date:  2008-06       Impact factor: 1.582

7.  One in four patients with follicular thyroid cytology (THY3) has a thyroid carcinoma.

Authors:  Radu Mihai; Andrew J C Parker; Derek Roskell; Gregory P Sadler
Journal:  Thyroid       Date:  2009-01       Impact factor: 6.568

8.  Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations.

Authors:  Jack Yang; Vicki Schnadig; Roberto Logrono; Patricia G Wasserman
Journal:  Cancer       Date:  2007-10-25       Impact factor: 6.860

9.  Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care.

Authors:  B Hamberger; H Gharib; L J Melton; J R Goellner; A R Zinsmeister
Journal:  Am J Med       Date:  1982-09       Impact factor: 4.965

10.  The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation.

Authors:  Zubair W Baloch; Edmund S Cibas; Douglas P Clark; Lester J Layfield; Britt-Marie Ljung; Martha Bishop Pitman; Andrea Abati
Journal:  Cytojournal       Date:  2008-04-07       Impact factor: 2.091

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  2 in total

1.  Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status.

Authors:  Irini S Hadjisavva; Roberto Dina; Michael A Talias; Panayiotis A Economides
Journal:  Eur Thyroid J       Date:  2015-05-30

2.  Follicular nodules (Thy3) of the thyroid: is total thyroidectomy the best option?

Authors:  Pietro Giorgio Calò; Fabio Medas; Rosa Santa Cruz; Francesco Podda; Enrico Erdas; Giuseppe Pisano; Angelo Nicolosi
Journal:  BMC Surg       Date:  2014-03-06       Impact factor: 2.102

  2 in total

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