| Literature DB >> 21475985 |
Yukihiro Sato1, Hiroyuki Sato, Keisuke Naka, Satoshi Furuya, Haruhisa Tsukiji, Koji Kitagawa, Yoshihide Sonoda, Takanobu Usui, Hirotsugu Sakamoto, Sumi Yoshino, Yuko Shimizu, Masaharu Takahashi, Shigeo Nagashima, Tsutomu Nishizawa, Hiroaki Okamoto.
Abstract
To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.Entities:
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Year: 2011 PMID： 21475985 DOI： 10.1007/s00705-011-0988-x
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574