Literature DB >> 21475541

Role of stem cells in treatment of neurological disorder.

Ashfaq Ul Hassan1, Ghulam Hassan, Zahida Rasool.   

Abstract

Stem cells or mother or queen of all cells are pleuropotent and have the remarkable potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell. Stem cells differ from other kinds of cells in the body. All stem cells regardless of their source have three general properties:They are unspecialized; one of the fundamental properties of a stem cell is that it does not have any tissue-specific structures that allow it to perform specialized functions.They can give rise to specialized cell types. These unspecialized stem cells can give rise to specialized cells, including heart muscle cells, blood cells, or nerve cells.They are capable of dividing and renewing themselves for long periods. Unlike muscle cells, blood cells, or nerve cells -- which do not normally replicate themselves - stem cells may replicate many times. A starting population of stem cells that proliferates for many months in the laboratory can yield millions of cells. Today, donated organs and tissues are often used to replace those that are diseased or destroyed. Unfortunately, the number of people needing a transplant far exceeds the number of organs available for transplantation. Pleuropotent stem cells offer the possibility of a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities including Parkinson's and Alzheimer's diseases, spinal cord injury, stroke, Cerebral palsy, Battens disease, Amyotrophic lateral sclerosis, restoration of vision and other neuro degenerative diseases as well.

Entities:  

Year:  2009        PMID: 21475541      PMCID: PMC3068820     

Source DB:  PubMed          Journal:  Int J Health Sci (Qassim)        ISSN: 1658-3639


  11 in total

1.  Why neurosurgeons should care about stem cells.

Authors:  J N Bruce; A T Parsa
Journal:  Neurosurgery       Date:  2001-01       Impact factor: 4.654

2.  Stem cell treatment in Amyotrophic Lateral Sclerosis.

Authors:  Letizia Mazzini; Katia Mareschi; Ivana Ferrero; Elena Vassallo; Giuseppe Oliveri; Nicola Nasuelli; Gaia Donata Oggioni; Lucia Testa; Franca Fagioli
Journal:  J Neurol Sci       Date:  2007-06-19       Impact factor: 3.181

Review 3.  Alzheimer's disease and neural transplantation as prospective cell therapy.

Authors:  Alcyr A Oliveira; Helen M Hodges
Journal:  Curr Alzheimer Res       Date:  2005-01       Impact factor: 3.498

Review 4.  Feasibility of gene therapy for late neuronal ceroid lipofuscinosis.

Authors:  D Sondhi; N R Hackett; R L Apblett; S M Kaminsky; R G Pergolizzi; R G Crystal
Journal:  Arch Neurol       Date:  2001-11

Review 5.  Stem cell transplantation for neurodegenerative diseases.

Authors:  Anne E Rosser; Rike Zietlow; Stephen B Dunnett
Journal:  Curr Opin Neurol       Date:  2007-12       Impact factor: 5.710

Review 6.  Stem cell therapy for cerebral palsy.

Authors:  John Bartley; James E Carroll
Journal:  Expert Opin Biol Ther       Date:  2003-07       Impact factor: 4.388

Review 7.  Towards therapeutic application of ocular stem cells.

Authors:  Graziella Pellegrini; Michele De Luca; Yvan Arsenijevic
Journal:  Semin Cell Dev Biol       Date:  2007-09-16       Impact factor: 7.727

8.  Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

Authors:  A Ramón-Cueto; M I Cordero; F F Santos-Benito; J Avila
Journal:  Neuron       Date:  2000-02       Impact factor: 17.173

9.  DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.

Authors:  Shoshana Shendelman; Alan Jonason; Cecile Martinat; Thomas Leete; Asa Abeliovich
Journal:  PLoS Biol       Date:  2004-10-05       Impact factor: 8.029

10.  Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.

Authors:  Cecile Martinat; Shoshana Shendelman; Alan Jonason; Thomas Leete; M Flint Beal; Lichuan Yang; Thomas Floss; Asa Abeliovich
Journal:  PLoS Biol       Date:  2004-10-05       Impact factor: 8.029

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  9 in total

1.  SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases.

Authors:  Subodh Kumar Mishra; Neha Jain; Uma Shankar; Arpita Tawani; Amit Mishra; Amit Kumar
Journal:  Database (Oxford)       Date:  2018-01-01       Impact factor: 3.451

2.  Optimization of Multimodal Nanoparticles Internalization Process in Mesenchymal Stem Cells for Cell Therapy Studies.

Authors:  Mariana P Nucci; Javier B Mamani; Fernando A Oliveira; Igor S Filgueiras; Arielly H Alves; Matheus H Theinel; Luiz D Rodrigues; Luciana Marti; Lionel F Gamarra
Journal:  Pharmaceutics       Date:  2022-06-12       Impact factor: 6.525

3.  Cell therapy attempted as a novel approach for chronic traumatic brain injury - a pilot study.

Authors:  Alok Sharma; Hemangi Sane; Pooja Kulkarni; Jayanti Yadav; Nandini Gokulchandran; Hema Biju; Prerna Badhe
Journal:  Springerplus       Date:  2015-01-17

4.  Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy.

Authors:  Geeta Shroff
Journal:  Clin Transl Med       Date:  2016-10-20

Review 5.  Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases.

Authors:  Shripriya Singh; Akriti Srivastava; Pranay Srivastava; Yogesh K Dhuriya; Ankita Pandey; Dipak Kumar; Chetan S Rajpurohit
Journal:  Front Mol Biosci       Date:  2016-11-08

6.  Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit.

Authors:  Sajedeh Karami; Mohammad Mahdi Doroodmand; Mahnaz Taherianfar; Amir Mutabi-Alavi; Nahid Nagshgar
Journal:  Sci Rep       Date:  2021-02-11       Impact factor: 4.379

7.  A comparative study of the capability of MSCs isolated from different human tissue sources to differentiate into neuronal stem cells and dopaminergic-like cells.

Authors:  Nidaa A Ababneh; Ban Al-Kurdi; Fatima Jamali; Abdalla Awidi
Journal:  PeerJ       Date:  2022-03-17       Impact factor: 2.984

8.  Intrathecal transplantation of autologous bone marrow mononuclear cells in patients with sub-acute and chronic spinal cord injury: An open-label study.

Authors:  Alok Sharma; Hemangi Sane; Nandini Gokulchandran; Pooja Kulkarni; Alitta Jose; Vivek Nair; Rohit Das; Vaibhav Lakhanpal; Prerna Badhe
Journal:  Int J Health Sci (Qassim)       Date:  2020 Mar-Apr

Review 9.  Directing Axonal Growth: A Review on the Fabrication of Fibrous Scaffolds That Promotes the Orientation of Axons.

Authors:  Devindraan Sirkkunan; Belinda Pingguan-Murphy; Farina Muhamad
Journal:  Gels       Date:  2021-12-28
  9 in total

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