PURPOSE: To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vs recipient gender. METHODS: We limited this study to patients received bone marrow transplantation (BMT). In all, 172 patients received BMT at Keio University School of Medicine between January 2000 and May 2007. Of them, 136 recipients who survived at least 70 days were studied prospectively. We classified the 136 patients according to the gender of the donor and the recipient (group I: female to female; group II: male to male; group III: male to female; group IV: female to male). The incidence and severity of chronic graft-vs-host disease-associated dry eye were determined for each group. The donor gender was masked when we assessed dry eye and calculate the incidence. RESULTS: The incidence of dry eye was 47.4% for group I, 37.5% for group II, 58.6% for group III, and 42.9% for group IV. The percentage of patients with severe dry eye was 44.4, 50.0, 35.3, and 77.8% respectively. There was a significant difference between the percent severe dry eye/total dry eye incidences in groups III and IV (P=0.0375) (odds ratio, 7.6; 95% confidence interval, 1.00-101.01). CONCLUSIONS: Close attention must be paid to the development of dry eye in cases of female to male BMTs, because the ratio of severe/total dry eye is more common in cases of female to male BMTs than in other gender combination.
PURPOSE: To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vs recipient gender. METHODS: We limited this study to patients received bone marrow transplantation (BMT). In all, 172 patients received BMT at Keio University School of Medicine between January 2000 and May 2007. Of them, 136 recipients who survived at least 70 days were studied prospectively. We classified the 136 patients according to the gender of the donor and the recipient (group I: female to female; group II: male to male; group III: male to female; group IV: female to male). The incidence and severity of chronic graft-vs-host disease-associated dry eye were determined for each group. The donor gender was masked when we assessed dry eye and calculate the incidence. RESULTS: The incidence of dry eye was 47.4% for group I, 37.5% for group II, 58.6% for group III, and 42.9% for group IV. The percentage of patients with severe dry eye was 44.4, 50.0, 35.3, and 77.8% respectively. There was a significant difference between the percent severe dry eye/total dry eye incidences in groups III and IV (P=0.0375) (odds ratio, 7.6; 95% confidence interval, 1.00-101.01). CONCLUSIONS: Close attention must be paid to the development of dry eye in cases of female to male BMTs, because the ratio of severe/total dry eye is more common in cases of female to male BMTs than in other gender combination.
Authors: R P Gale; M M Bortin; D W van Bekkum; J C Biggs; K A Dicke; E Gluckman; R A Good; R G Hoffmann; H E Kay; J H Kersey Journal: Br J Haematol Date: 1987-12 Impact factor: 6.998
Authors: R A Nash; J H Antin; C Karanes; J W Fay; B R Avalos; A M Yeager; D Przepiorka; S Davies; F B Petersen; P Bartels; D Buell; W Fitzsimmons; C Anasetti; R Storb; V Ratanatharathorn Journal: Blood Date: 2000-09-15 Impact factor: 22.113
Authors: C Kollman; C W Howe; C Anasetti; J H Antin; S M Davies; A H Filipovich; J Hegland; N Kamani; N A Kernan; R King; V Ratanatharathorn; D Weisdorf; D L Confer Journal: Blood Date: 2001-10-01 Impact factor: 22.113
Authors: David B Miklos; Haesook T Kim; Emmanuel Zorn; Ephraim P Hochberg; Luxuan Guo; Alex Mattes-Ritz; Sebastien Viatte; Robert J Soiffer; Joseph H Antin; Jerome Ritz Journal: Blood Date: 2003-09-25 Impact factor: 22.113
Authors: D S Bross; P J Tutschka; E R Farmer; W E Beschorner; H G Braine; E D Mellits; W B Bias; G W Santos Journal: Blood Date: 1984-06 Impact factor: 22.113
Authors: Sophia S B Randolph; Theodore A Gooley; Edus H Warren; Frederick R Appelbaum; Stanley R Riddell Journal: Blood Date: 2003-09-11 Impact factor: 22.113
Authors: Yoshihiro Inamoto; Nuria Valdés-Sanz; Yoko Ogawa; Monica Alves; Luigi Berchicci; John Galvin; Hildegard Greinix; Gregory A Hale; Biljana Horn; Debra Kelly; Hien Liu; Scott Rowley; Helene Schoemans; Ami Shah; Maria Teresa Lupo Stanghellini; Vaibhav Agrawal; Ibrahim Ahmed; Asim Ali; Neel Bhatt; Michael Byrne; Saurabh Chhabra; Zachariah DeFilipp; Kristina Fahnehjelm; Nosha Farhadfar; Erich Horn; Catherine Lee; Sunita Nathan; Olaf Penack; Pinki Prasad; Seth Rotz; Alicia Rovó; Jean Yared; Steven Pavletic; Grzegorz W Basak; Minoo Battiwalla; Rafael Duarte; Bipin N Savani; Mary E D Flowers; Bronwen E Shaw; Igor Petriček Journal: Biol Blood Marrow Transplant Date: 2018-11-24 Impact factor: 5.742
Authors: Shahzad I Mian; Paola De la Parra-Colín; Rafael De Melo-Franco; Christopher Johnson; Tonatiuh Barrientos-Gutierrez Journal: Trans Am Ophthalmol Soc Date: 2015-09
Authors: Rena C Zuo; Haley B Naik; Seth M Steinberg; Kristin Baird; Sandra A Mitchell; Zoya Kuzmina; Steven Z Pavletic; Edward W Cowen Journal: JAMA Dermatol Date: 2015-01 Impact factor: 10.282