Literature DB >> 21474364

Feasibility of Tomotherapy to spare the cochlea from excessive radiation in head and neck cancer.

Nam P Nguyen1, Lexie Smith-Raymond, Vincent Vinh-Hung, Devin Sloan, Rick Davis, Paul Vos, Dave Abraham, Michelle Stevie, Shane Paul Krafft, Bevan Hong Ly, Tiffany Ries, Ulf Karlsson, Misty Ceizyk.   

Abstract

We would like to evaluate the effectiveness of Tomotherapy for decreasing radiation dose to the cochlea in head and neck cancer patients. A retrospective review of 72 patients undergoing radiation for head and neck cancer was performed. Cochlea dose was compared between 20 patients treated with conventional intensity modulated radiotherapy (IMRT) and 52 treated with Tomotherapy. A review of literature was performed to assess cochlea dose reported with the IMRT technique for head and neck cancer. Mean total cochlea dose was 36 Gy for IMRT compared to 12.1 Gy for Tomotherapy (p=0.002). Mean right cochlea dose was respectively, 16.6 and 6.2 Gy for IMRT and Tomotherapy (p=0.007), and 19.3 and 5.9 Gy for the left. Cochlea (p=0.002). Mean cochlea dose reported in the literature ranged from 16 to 55 Gy with IMRT for head and neck cancer. Helical Tomotherapy for head and neck cancer may significantly decrease radiation dose to the cochlea without sacrificing target volume coverage.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21474364     DOI: 10.1016/j.oraloncology.2011.03.011

Source DB:  PubMed          Journal:  Oral Oncol        ISSN: 1368-8375            Impact factor:   5.337


  12 in total

1.  Unilateral cochlea sparing in locoregionally advanced head and neck cancer: a planning study.

Authors:  L H Braun; K Braun; B Frey; S M Wolpert; H Löwenheim; D Zips; S Welz
Journal:  Strahlenther Onkol       Date:  2018-08-14       Impact factor: 3.621

2.  Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer.

Authors:  Nam P Nguyen; Jacqueline Vock; Vincent Vinh-Hung; Fabio Almeida; Lars Ewell; Michael Betz; Siyoung Jang; Richard A Vo; Suresh Dutta; Juan Godinez; Ulf Karlsson; Alexander Chi
Journal:  BMC Cancer       Date:  2012-06-18       Impact factor: 4.430

Review 3.  Potential applications of imaging and image-guided radiotherapy for brain metastases and glioblastoma to improve patient quality of life.

Authors:  Nam P Nguyen; Mai L Nguyen; Jacqueline Vock; Claire Lemanski; Christine Kerr; Vincent Vinh-Hung; Alexander Chi; Rihan Khan; William Woods; Gabor Altdorfer; Mark D'Andrea; Ulf Karlsson; Russ Hamilton; Fred Ampil
Journal:  Front Oncol       Date:  2013-11-19       Impact factor: 6.244

Review 4.  Image-guided radiotherapy for cardiac sparing in patients with left-sided breast cancer.

Authors:  Claire Lemanski; Juliette Thariat; Federico L Ampil; Satya Bose; Jacqueline Vock; Rick Davis; Alexander Chi; Suresh Dutta; William Woods; Anand Desai; Juan Godinez; Ulf Karlsson; Melissa Mills; Nam Phong Nguyen; Vincent Vinh-Hung
Journal:  Front Oncol       Date:  2014-09-23       Impact factor: 6.244

5.  A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma.

Authors:  Xinxin Zhang; Lei Du; Feifang Zhao; Qiuju Wang; Shiming Yang; Lin Ma
Journal:  Int J Biol Sci       Date:  2016-02-12       Impact factor: 6.580

Review 6.  Feasibility of intensity-modulated and image-guided radiotherapy for functional organ preservation in locally advanced laryngeal cancer.

Authors:  Nam P Nguyen; Alexander Chi; Michael Betz; Fabio Almeida; Paul Vos; Rick Davis; Benjamin Slane; Misty Ceizyk; Dave Abraham; Lexie Smith-Raymond; Michelle Stevie; Siyoung Jang; Steven Gelumbauskas; Vincent Vinh-Hung
Journal:  PLoS One       Date:  2012-08-20       Impact factor: 3.240

7.  Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer.

Authors:  Nam P Nguyen; Misty Ceizyk; Paul Vos; Michael Betz; Alexander Chi; Fabio Almeida; Rick Davis; Benjamin Slane; Steven Gelumbauskas; Lexie Smith-Raymond; Dave Abraham; Michelle Stevie; Siyoung Jang; Vincent Vinh-Hung
Journal:  PLoS One       Date:  2013-03-28       Impact factor: 3.240

8.  Image-guided radiotherapy for locally advanced head and neck cancer.

Authors:  Nam P Nguyen; Sarah Kratz; Claire Lemanski; Jacqueline Vock; Vincent Vinh-Hung; Alexander Chi; Fabio Almeida; Michael Betz; Rihan Khan; Juan Godinez; Ulf Karlsson; Fred Ampil
Journal:  Front Oncol       Date:  2013-07-08       Impact factor: 6.244

9.  Helical tomotherapy in children and adolescents: dosimetric comparisons, opportunities and issues.

Authors:  Maurizio Mascarin; Francesca Maria Giugliano; Elisa Coassin; Annalisa Drigo; Paola Chiovati; Andrea Dassie; Giovanni Franchin; Emilio Minatel; Mauro Gaetano Trovò
Journal:  Cancers (Basel)       Date:  2011-10-25       Impact factor: 6.639

10.  Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer.

Authors:  Nam P Nguyen; Wei Shen; Sarah Kratz; Jacqueline Vock; Paul Vos; Vinh-Hung Vincent; Gabor Altdorfer; Lars Ewell; Siyoung Jang; Ulf Karlsson; Juan Godinez; Melissa Mills; Thomas Sroka; Suresh Dutta; Alexander Chi
Journal:  Front Oncol       Date:  2013-11-26       Impact factor: 6.244

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