| Literature DB >> 21474215 |
Wei Bi1, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Michele Baudy-Floc'h, Nathaniel Ngerebara, Xiaoxu Li, K Michael Gibson, Lanrong Bi.
Abstract
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat. Published by Elsevier Masson SAS.Entities:
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Year: 2011 PMID： 21474215 DOI： 10.1016/j.ejmech.2011.03.029
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514