| Literature DB >> 21474063 |
Debaditya Mukhopadhyay1, Michael J Matunis.
Abstract
An intimate relationship exists between the transcriptional coregulator Daxx, SUMO, and PML nuclear bodies. In this issue, Chang et al. (2011) provide structural insights into how phosphorylation of Daxx increases its affinity toward SUMOs and functional insights into how enhanced SUMO binding affects Daxx-PML interactions, PML nuclear body localization, and Daxx-mediated repression of genes encoding for antiapoptotic factors.Entities:
Year: 2011 PMID: 21474063 PMCID: PMC3074294 DOI: 10.1016/j.molcel.2011.03.008
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970