BACKGROUND AND OBJECTIVES: Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain. CONTENTS: This article reviews the effects of cytokines in pain. In diseases with acute or chronic inflammation, cytokines can be recognized by neurons and used to trigger several cell reactions that influence the activity, proliferation, and survival of immune cells, as well as the production and activity of other cytokines. Cytokines can be proinflammatory and anti-inflammatory. Proinflammatory cytokines are related with the pathophysiology of pain syndromes. Cells that secrete proinflammatory (IL-1, IL-2, IL-6, IL-7, and TNF) and anti-inflammatory (IL-4, IL-10, IL-13, and TGFβ) cytokines, the functions of each cytokine, and the action of those compounds on pain processing, have been described. CONCLUSIONS: Cytokines have an important role in pain through different mechanisms in several sites of pain transmission pathways.
BACKGROUND AND OBJECTIVES: Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain. CONTENTS: This article reviews the effects of cytokines in pain. In diseases with acute or chronic inflammation, cytokines can be recognized by neurons and used to trigger several cell reactions that influence the activity, proliferation, and survival of immune cells, as well as the production and activity of other cytokines. Cytokines can be proinflammatory and anti-inflammatory. Proinflammatory cytokines are related with the pathophysiology of pain syndromes. Cells that secrete proinflammatory (IL-1, IL-2, IL-6, IL-7, and TNF) and anti-inflammatory (IL-4, IL-10, IL-13, and TGFβ) cytokines, the functions of each cytokine, and the action of those compounds on pain processing, have been described. CONCLUSIONS: Cytokines have an important role in pain through different mechanisms in several sites of pain transmission pathways.
Authors: Marilyn Huckans; Bret Fuller; Viva Wheaton; Sarah Jaehnert; Carilyn Ellis; Michael Kolessar; Daniel Kriz; Jeanne Renee Anderson; Kristin Berggren; Hannah Olavarria; Anna W Sasaki; Michael Chang; Kenneth D Flora; Jennifer M Loftis Journal: J Psychosom Res Date: 2014-08-07 Impact factor: 3.006
Authors: Jennifer Fazzari; Jesse Sidhu; Shreya Motkur; Mark Inman; Norman Buckley; Mark Clemons; Lisa Vandermeer; Gurmit Singh Journal: J Pain Res Date: 2020-02-07 Impact factor: 3.133
Authors: Hiam Marcon; Luiz G Griss; Vitor L Molosse; Bruno G O Cecere; Davi F Alba; Karoline W Leal; Gabriela M Galli; Carine F Souza; Matheus D Baldissera; Samanta Gundel; Vitória de A Bassotto; Aline F Ourique; Marcelo Vedovatto; Aleksandro S Da Silva Journal: Anim Nutr Date: 2021-03-17
Authors: Larissa B Cardozo; Lourenço C Cotes; Marcia A P Kahvegian; Maria Fernanda C I Rizzo; Denise A Otsuki; Cassio R A Ferrigno; Denise T Fantoni Journal: BMC Vet Res Date: 2014-09-06 Impact factor: 2.741