BACKGROUND: Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS: We examined the association between changes in lifestyle factors and changes in HDL-C over a 14-year period in a cohort of 4,168 US male physicians, followed up between 1982 and 1997 and with HDL-C measured at both time points. Using linear regression, we examined the association between HDL-C change and categorized changes in alcohol consumption, physical activity, body mass index (BMI), and smoking, adjusting for age, baseline HDL-C, and other covariates. RESULTS: Stable BMI of <25 kg/m(2) or BMI reduction from ≥25 to <25 kg/m(2) were associated with increases in HDL-C of 3.1 to 4.7 mg/dL over 14 years. Alcohol consumption of ≥1 drink daily or increase in alcohol consumption from <1 to ≥1 drink daily was associated with increases in HDL-C of 2.4 to 3.3 mg/dL over 14 years. Adopting a sedentary lifestyle was associated with decreases in 14-year decreases in HDL-C. CONCLUSION: These findings suggest that reductions in BMI and increases in alcohol consumption are associated with 14-year increases in HDL-C, whereas decreases in physical activity are associated with 14-year decreases in HDL-C.
BACKGROUND: Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS: We examined the association between changes in lifestyle factors and changes in HDL-C over a 14-year period in a cohort of 4,168 US male physicians, followed up between 1982 and 1997 and with HDL-C measured at both time points. Using linear regression, we examined the association between HDL-C change and categorized changes in alcohol consumption, physical activity, body mass index (BMI), and smoking, adjusting for age, baseline HDL-C, and other covariates. RESULTS: Stable BMI of <25 kg/m(2) or BMI reduction from ≥25 to <25 kg/m(2) were associated with increases in HDL-C of 3.1 to 4.7 mg/dL over 14 years. Alcohol consumption of ≥1 drink daily or increase in alcohol consumption from <1 to ≥1 drink daily was associated with increases in HDL-C of 2.4 to 3.3 mg/dL over 14 years. Adopting a sedentary lifestyle was associated with decreases in 14-year decreases in HDL-C. CONCLUSION: These findings suggest that reductions in BMI and increases in alcohol consumption are associated with 14-year increases in HDL-C, whereas decreases in physical activity are associated with 14-year decreases in HDL-C.
Authors: Richard Scranton; Howard D Sesso; Meir J Stampfer; James W Levenson; Julie E Buring; J Michael Gaziano Journal: Am Heart J Date: 2004-06 Impact factor: 4.749
Authors: B Asztalos; M Lefevre; L Wong; T A Foster; R Tulley; M Windhauser; W Zhang; P S Roheim Journal: J Lipid Res Date: 2000-03 Impact factor: 5.922
Authors: A S Leon; S E Gaskill; T Rice; J Bergeron; J Gagnon; D C Rao; J S Skinner; J H Wilmore; C Bouchard Journal: Int J Sports Med Date: 2002-01 Impact factor: 3.118
Authors: Lydia C Siegel; Howard D Sesso; Thomas S Bowman; I-Min Lee; JoAnn E Manson; J Michael Gaziano Journal: Am J Med Date: 2009-12 Impact factor: 4.965
Authors: R Curtis Ellison; Yuqing Zhang; Muhammad Mustafa Qureshi; Sarah Knox; Donna K Arnett; Michael A Province Journal: Am Heart J Date: 2004-03 Impact factor: 4.749
Authors: Howard D Sesso; J Michael Gaziano; Martin VanDenburgh; Charles H Hennekens; Robert J Glynn; Julie E Buring Journal: Control Clin Trials Date: 2002-12