Literature DB >> 21473850

NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli.

Daria V Ilatovskaya1, Vladislav Levchenko, Robert P Ryan, Allen W Cowley, Alexander Staruschenko.   

Abstract

Using a novel approach for analysis of TRPC channel activity, we report here that NSAIDs are involved into regulation of TRPC channels in the podocytes of the freshly isolated decapsulated glomeruli. Fluorescence and electron microscopy techniques confirmed the integrity of podocytes in the glomeruli. Western blotting showed that TRPC1, 3 and 6 are highly expressed in the glomeruli. Single-channel patch clamp analysis revealed cation currents with distinct TRPC properties. This is the first report describing single TRPC-like currents in glomerular podocytes. Furthermore, our data provide a novel mechanism of NSAIDs regulation of TRPC channels, which might be implicated in maintaining the glomerular filtration barrier.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21473850      PMCID： PMC3093766          DOI： 10.1016/j.bbrc.2011.04.005

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

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Authors:  Hermann Pavenstädt; Martin Bek
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3.  Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats.

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Review 4.  TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.

Authors:  Stuart E Dryer; Jochen Reiser
Journal:  Am J Physiol Renal Physiol       Date:  2010-08-04

5.  Angiotensin II depolarizes podocytes in the intact glomerulus of the Rat.

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Journal:  J Clin Invest       Date:  1997-06-01       Impact factor: 14.808

6.  Catecholamines modulate podocyte function.

Authors:  T B Huber; J Gloy; A Henger; P Schollmeyer; R Greger; P Mundel; H Pavenstädt
Journal:  J Am Soc Nephrol       Date:  1998-03       Impact factor: 10.121

7.  Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals.

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  12 in total

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Review 6.  TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

Authors:  Daria V Ilatovskaya; Alexander Staruschenko
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7.  Single-channel analysis of TRPC channels in the podocytes of freshly isolated Glomeruli.

Authors:  Daria V Ilatovskaya; Alexander Staruschenko
Journal:  Methods Mol Biol       Date:  2013

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