| Literature DB >> 21473585 |
Tsugio Kitamura1, Satoshi Kuriki, Mohammad Hasan Morshed, Yuji Hori.
Abstract
A simple, practical, and convenient fluorination of 1,3-dicarbonyl compounds was achieved by direct use of aqueous hydrofluoric acid and iodosylbenzene (PhIO). The reaction of ethyl benzoylacetate with the reagent system of aqueous HF and PhIO in CH(2)Cl(2) gave ethyl 2-fluoro-2-benzolyacetate in 98% yield. Other 1,3-dicarbonyl compounds including β-keto esters and 1,3-diketones underwent the fluorination reaction to give the corresponding fluorinated products in good yields.Entities:
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Year: 2011 PMID： 21473585 DOI： 10.1021/ol200632d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005