[Regulators of hormonal signalling system on the basis of peptides, derivatives of receptors of the serpentine type].

In the review, own results and the data of other authors concerning synthetic peptides corresponding to intracellular and transmembrane regions of receptors of the serpentine type, which are responsible for the interaction with G-proteins and for the formation of ligand-binding site, are analyzed. These peptides affect the basal activity of hormonal signalling systems and the transduction of hormonal signal from the latter with high selectivity and efficiency. Possible molecular mechanisms of the action of peptides, the perspectives of development of a new generation of drugs for the control of endocrine function and physiological processes in the organism on the basis of receptor-based peptides, and their application as functional probes for study of structural-functional organization of hormonal signalling systems are considered.