Literature DB >> 21472651

New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn.

Karen L Lang1, Tatiana da Rosa Guimarães, Vanessa Rocha Machado, Lara A Zimmermann, Izabella T Silva, Marina R Teixeira, Fernando J Durán, Jorge A Palermo, Cláudia M O Simões, Miguel S B Caro, Eloir P Schenkel.   

Abstract

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2011        PMID： 21472651     DOI： 10.1055/s-0030-1270962

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  2 in total

1.  Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549.

Authors:  Izabella Thaís Silva; Fabiana Cristina Geller; Lara Persich; Sabine Eva Dudek; Karen Luise Lang; Miguel Soriano Balparda Caro; Fernando Javier Durán; Eloir Paulo Schenkel; Stephan Ludwig; Cláudia Maria Oliveira Simões
Journal:  Invest New Drugs       Date:  2016-01-16       Impact factor: 3.850

2.  In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B.

Authors:  Izabella T Silva; Annelise Carvalho; Karen L Lang; Sabine E Dudek; Dörthe Masemann; Fernando J Durán; Miguel S B Caro; Ulf R Rapp; Viktor Wixler; Eloir P Schenkel; Cláudia M O Simões; Stephan Ludwig
Journal:  PLoS One       Date:  2015-02-12       Impact factor: 3.240
  2 in total

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