Literature DB >> 2147227

Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.

W Knepel1, J Chafitz, J F Habener.   

Abstract

The 5'-flanking region of the rat glucagon gene contains, from nucleotides -291 to -298, a sequence (TGA CGTCA) which mediates cyclic AMP (cAMP) responsiveness in several genes (cAMP-responsive element [CRE]). However, because of nonpermissive bases surrounding the CRE octamer, the glucagon CRE does not confer cAMP responsiveness to an inert heterologous promoter in placental JEG cells that do not express the glucagon gene. This report describes transient transfection experiments with glucagon-reporter fusion genes that show that glucagon gene expression is activated by cAMP-dependent protein kinase A in a glucagon-expressing pancreatic islet cell line. This activation is mediated through the glucagon CRE.

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Year:  1990        PMID： 2147227      PMCID： PMC362961          DOI： 10.1128/mcb.10.12.6799-6804.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  27 in total

1.  Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.

Authors:  J M Ntambi; S A Buhrow; K H Kaestner; R J Christy; E Sibley; T J Kelly; M D Lane
Journal:  J Biol Chem       Date:  1988-11-25       Impact factor: 5.157

Review 2.  Cyclic AMP and the induction of eukaryotic gene transcription.

Authors:  W J Roesler; G R Vandenbark; R W Hanson
Journal:  J Biol Chem       Date:  1988-07-05       Impact factor: 5.157

3.  Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40-transformed B cells.

Authors:  P Hammonds; P N Schofield; S J Ashcroft
Journal:  FEBS Lett       Date:  1987-03-09       Impact factor: 4.124

4.  Multiple adenosine 3',5'-cyclic [corrected] monophosphate response element DNA-binding proteins generated by gene diversification and alternative exon splicing.

Authors:  J P Hoeffler; T E Meyer; G Waeber; J F Habener
Journal:  Mol Endocrinol       Date:  1990-06

5.  Interplay of nutrients and hormones in the regulation of glucagon release.

Authors:  D G Pipeleers; F C Schuit; C F Van Schravendijk; M Van de Winkel
Journal:  Endocrinology       Date:  1985-09       Impact factor: 4.736

6.  Isolation of glucagon-secreting cell lines by cloning insulinoma cells.

Authors:  R Takaki; J Ono; M Nakamura; Y Yokogawa; S Kumae; T Hiraoka; K Yamaguchi; K Hamaguchi; S Uchida
Journal:  In Vitro Cell Dev Biol       Date:  1986-03

7.  Adrenergic receptors and the secretion of glucagon and insulin from the isolated, perfused canine pancreas.

Authors:  J Iversen
Journal:  J Clin Invest       Date:  1973-09       Impact factor: 14.808

8.  Proglucagon gene expression and posttranslational processing in a hamster islet cell line.

Authors:  D J Drucker; J Philippe; S Mojsov
Journal:  Endocrinology       Date:  1988-10       Impact factor: 4.736

9.  Firefly luciferase gene: structure and expression in mammalian cells.

Authors:  J R de Wet; K V Wood; M DeLuca; D R Helinski; S Subramani
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

10.  Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures.

Authors:  P L Brubaker
Journal:  Endocrinology       Date:  1988-07       Impact factor: 4.736
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  17 in total

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Authors:  Prasad S Dalvi; Frederick D Erbiceanu; David M Irwin; Denise D Belsham
Journal:  Mol Endocrinol       Date:  2012-06-05

Review 2.  Glucagon-like peptide 1 (GLP-1).

Authors:  T D Müller; B Finan; S R Bloom; D D'Alessio; D J Drucker; P R Flatt; A Fritsche; F Gribble; H J Grill; J F Habener; J J Holst; W Langhans; J J Meier; M A Nauck; D Perez-Tilve; A Pocai; F Reimann; D A Sandoval; T W Schwartz; R J Seeley; K Stemmer; M Tang-Christensen; S C Woods; R D DiMarchi; M H Tschöp
Journal:  Mol Metab       Date:  2019-09-30       Impact factor: 7.422

3.  Glucagon regulates its own synthesis by autocrine signaling.

Authors:  Barbara Leibiger; Tilo Moede; Thusitha P Muhandiramlage; Daniel Kaiser; Pilar Vaca Sanchez; Ingo B Leibiger; Per-Olof Berggren
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-03       Impact factor: 11.205

4.  Homologous DNA sequences and cellular factors are implicated in the control of glucagon and insulin gene expression.

Authors:  M Cordier-Bussat; C Morel; J Philippe
Journal:  Mol Cell Biol       Date:  1995-07       Impact factor: 4.272

Review 5.  The role of incretins in glucose homeostasis and diabetes treatment.

Authors:  Wook Kim; Josephine M Egan
Journal:  Pharmacol Rev       Date:  2008-12-12       Impact factor: 25.468

6.  Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element.

Authors:  J-C Gevrey; M Malapel; J Philippe; G Mithieux; J-A Chayvialle; J Abello; M Cordier-Bussat
Journal:  Diabetologia       Date:  2004-04-14       Impact factor: 10.122

7.  Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells.

Authors:  D M Kendall; V Poitout; L K Olson; R L Sorenson; R P Robertson
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

8.  Cyclic adenosine monophosphate prevents the glucocorticoid-mediated inhibition of insulin gene expression in rodent islet cells.

Authors:  J Philippe; E Giordano; A Gjinovci; P Meda
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

9.  POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.

Authors:  Peixiang Wang; Qinghua Wang; Jane Sun; Jing Wu; Hang Li; Nina Zhang; Yachi Huang; Brenda Su; Ren-ke Li; Ling Liu; Yi Zhang; Harry P Elsholtz; Jim Hu; Herbert Y Gaisano; Tianru Jin
Journal:  J Biol Chem       Date:  2009-07-18       Impact factor: 5.157

10.  The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line.

Authors:  M Schwaninger; R Blume; E Oetjen; W Knepel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-11       Impact factor: 3.000
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