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Literature DB >> 21472002

Brain metastases as preventive and therapeutic targets.

Patricia S Steeg¹, Kevin A Camphausen, Quentin R Smith.

Abstract

The incidence of metastasis to the brain is apparently rising in cancer patients and threatens to limit the gains that have been made by new systemic treatments. The brain is considered a 'sanctuary site' as the blood-tumour barrier limits the ability of drugs to enter and kill tumour cells. Translational research examining metastasis to the brain needs to be multi-disciplinary, marrying advanced chemistry, blood-brain barrier pharmacokinetics, neurocognitive testing and radiation biology with metastasis biology, to develop and implement new clinical trial designs. Advances in the chemoprevention of brain metastases, the validation of tumour radiation sensitizers and the amelioration of cognitive deficits caused by whole-brain radiation therapy are discussed.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Antineoplastic Agents

Year: 2011 PMID： 21472002 PMCID： PMC7351203 DOI： 10.1038/nrc3053

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

139 in total

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Journal: Curr Med Chem Date: 2009 Impact factor: 4.530

4. Brain metastasis model in athymic nude mice using a novel MUC1-secreting human breast-cancer cell line, MA11.

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6. Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.

Authors: Jens Hoffmann; Iduna Fichtner; Margit Lemm; Philip Lienau; Holger Hess-Stumpp; Andrea Rotgeri; Birte Hofmann; Ulrich Klar
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7. Prophylactic cranial irradiation in extensive small-cell lung cancer.

Authors: Ben Slotman; Corinne Faivre-Finn; Gijs Kramer; Elaine Rankin; Michael Snee; Matthew Hatton; Pieter Postmus; Laurence Collette; Elena Musat; Suresh Senan
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8. The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation.

Authors: Sriram Ramanan; Mitra Kooshki; Weiling Zhao; Fang-Chi Hsu; David R Riddle; Mike E Robbins
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9. An experimental model of brain metastasis of lung carcinoma.

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10. Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer.

Authors: Jochen Gaedcke; Frank Traub; Simone Milde; Ludwig Wilkens; Alexandru Stan; Helmut Ostertag; Mathias Christgen; Reinhard von Wasielewski; Hans H Kreipe
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155 in total

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2. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells.

Authors: Daniel P Fitzgerald; David L Emerson; Yongzhen Qian; Talha Anwar; David J Liewehr; Seth M Steinberg; Sandra Silberman; Diane Palmieri; Patricia S Steeg
Journal: Mol Cancer Ther Date: 2012-05-23 Impact factor: 6.261

Review 3. Therapeutic approaches for HER2-positive brain metastases: circumventing the blood-brain barrier.

Authors: Ankit I Mehta; Adam M Brufsky; John H Sampson
Journal: Cancer Treat Rev Date: 2012-06-22 Impact factor: 12.111

4. Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.

Authors: Yongzhen Qian; Emily Hua; Kheem Bisht; Stephan Woditschka; Konstantine W Skordos; David J Liewehr; Seth M Steinberg; Edi Brogi; Muzaffar M Akram; J Keith Killian; Daniel C Edelman; Marbin Pineda; Stephanie Scurci; Yan Y Degenhardt; Sylvie Laquerre; Thomas A Lampkin; Paul S Meltzer; Kevin Camphausen; Patricia S Steeg; Diane Palmieri
Journal: Clin Exp Metastasis Date: 2011-09-21 Impact factor: 5.150

5. Cancer: Organ-seeking vesicles.

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6. Clinical and molecular characteristics of HNSCC patients with brain metastases: a retrospective study.

Authors: Olcay Cem Bulut; Katja Lindel; Henrik Hauswald; Regine Brandt; Frederick Klauschen; Janina Wolf; Thomas Wolf; Peter K Plinkert; Christian Simon; Wilko Weichert; Albrecht Stenzinger
Journal: Eur Arch Otorhinolaryngol Date: 2013-08-29 Impact factor: 2.503