L C Chan1, Samuel K W Chiu, Stephen L Chan. 1. Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong. lc_chan@clo.cuhk.edu.hk
Abstract
OBJECTIVE: To evaluate the efficacy and toxicities of stereotactic radiotherapy for unresectable hepatocellular carcinoma. DESIGN: Retrospective study. SETTING: Prince of Wales Hospital, Hong Kong. MAIN OUTCOME MEASURES: Treatment outcome and toxicities. PATIENTS: During the period of 2000 to 2004, 16 patients with hepatocellular carcinoma treated with stereotactic radiotherapy were reviewed. RESULTS: Of the 16 patients, 11 had assessable responses. For local control, there were two complete and three partial responses, five with stable disease and one with progressive disease, giving a local response rate of 45% and control rate of 91%. The median survival was 23 months. The 1-year and 3-year overall survival rates were 62% and 28%, respectively. The most frequent site of recurrence was intrahepatic but outside the irradiated field. Two patients with Child-Pugh B cirrhosis developed radiation-induced liver disease. No other grade 3/4 toxicities were recorded. CONCLUSION: Stereotactic radiotherapy gives high local control rates and has the potential to prolong survival in patients with hepatocellular carcinoma. It is safe and tolerable in Child-Pugh A patients.
OBJECTIVE: To evaluate the efficacy and toxicities of stereotactic radiotherapy for unresectable hepatocellular carcinoma. DESIGN: Retrospective study. SETTING: Prince of Wales Hospital, Hong Kong. MAIN OUTCOME MEASURES: Treatment outcome and toxicities. PATIENTS: During the period of 2000 to 2004, 16 patients with hepatocellular carcinoma treated with stereotactic radiotherapy were reviewed. RESULTS: Of the 16 patients, 11 had assessable responses. For local control, there were two complete and three partial responses, five with stable disease and one with progressive disease, giving a local response rate of 45% and control rate of 91%. The median survival was 23 months. The 1-year and 3-year overall survival rates were 62% and 28%, respectively. The most frequent site of recurrence was intrahepatic but outside the irradiated field. Two patients with Child-Pugh B cirrhosis developed radiation-induced liver disease. No other grade 3/4 toxicities were recorded. CONCLUSION: Stereotactic radiotherapy gives high local control rates and has the potential to prolong survival in patients with hepatocellular carcinoma. It is safe and tolerable in Child-Pugh A patients.
Authors: Betul Berber; Rafael Ibarra; Laura Snyder; Min Yao; Jeffrey Fabien; Michael T Milano; Alan W Katz; Karyn Goodman; Kevin Stephans; Galal El-Gazzaz; Federico Aucejo; Charles Miller; John Fung; Simon Lo; Mitchell Machtay; Juan Sanabria Journal: HPB (Oxford) Date: 2013-01-14 Impact factor: 3.647
Authors: Michael I Lock; Jonathan Klein; Hans T Chung; Joseph M Herman; Edward Y Kim; William Small; Nina A Mayr; Simon S Lo Journal: World J Hepatol Date: 2017-05-18