Literature DB >> 21471432

HIV transmission: time for translational studies to bridge the gap.

Peter Anton1, Betsy C Herold.   

Abstract

More than 7000 new HIV infections are documented each day worldwide. In this Perspective, we dissect new results from a large clinical trial showing that genital and plasma HIV-1 RNA loads predict the risk of heterosexual transmission and that genital tract viral RNA load does so independently of plasma viral load. Furthermore, beyond its defined study end points, this well-conducted trial identified new research directions that should be pursued in smaller intensive basic and translational studies.

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Year:  2011        PMID： 21471432      PMCID： PMC3767382          DOI： 10.1126/scitranslmed.3002329

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  42 in total

1.  Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue.

Authors:  P A Anton; J Elliott; M A Poles; I M McGowan; J Matud; L E Hultin; K Grovit-Ferbas; C R Mackay; J V Giorgi
Journal:  AIDS       Date:  2000-08-18       Impact factor: 4.177

2.  Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2011-01-28       Impact factor: 17.586

3.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

Review 4.  Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings.

Authors:  Gavin M Myers; Kenneth H Mayer
Journal:  AIDS Patient Care STDS       Date:  2011-02       Impact factor: 5.078

5.  Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates.

Authors:  C W Hendrix; E J Fuchs; K J Macura; L A Lee; T L Parsons; R P Bakshi; W A Khan; A Guidos; J P Leal; R Wahl
Journal:  Clin Pharmacol Ther       Date:  2007-05-16       Impact factor: 6.875

6.  Reassessing the hypothesis on STI control for HIV prevention.

Authors:  Ronald H Gray; Maria J Wawer
Journal:  Lancet       Date:  2008-06-21       Impact factor: 79.321

7.  Modeling the potential impact of rectal microbicides to reduce hiv transmission in bathhouses.

Authors:  Romulus Breban; Ian McGowan; Chad Topaz; Elissa J Schwartz; Peter Anton; Sally Blower
Journal:  Math Biosci Eng       Date:  2006-07       Impact factor: 2.080

8.  Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults.

Authors:  Karen E Mark; Anna Wald; Amalia S Magaret; Stacy Selke; Steven Kuntz; Meei-Li Huang; Lawrence Corey
Journal:  J Acquir Immune Defic Syndr       Date:  2010-08       Impact factor: 3.731

9.  Anal sex, vaginal practices, and HIV incidence in female sex workers in urban Kenya: implications for the development of intravaginal HIV prevention methods.

Authors:  Frances H Priddy; Sabina Wakasiaka; Tina D Hoang; Donna J Smith; Bashir Farah; Carlos del Rio; Jeckoniah Ndinya-Achola
Journal:  AIDS Res Hum Retroviruses       Date:  2011-05-06       Impact factor: 2.205

10.  Semen-derived amyloid fibrils drastically enhance HIV infection.

Authors:  Jan Münch; Elke Rücker; Ludger Ständker; Knut Adermann; Christine Goffinet; Michael Schindler; Steffen Wildum; Raghavan Chinnadurai; Devi Rajan; Anke Specht; Guillermo Giménez-Gallego; Pedro Cuevas Sánchez; Douglas M Fowler; Atanas Koulov; Jeffery W Kelly; Walther Mothes; Jean-Charles Grivel; Leonid Margolis; Oliver T Keppler; Wolf-Georg Forssmann; Frank Kirchhoff
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582
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  7 in total

1.  Future prospects and perspectives on microbicides.

Authors:  Peter A Anton
Journal:  Curr HIV Res       Date:  2012-01-01       Impact factor: 1.581

Review 2.  Contraceptive methods and risk of HIV acquisition or female-to-male transmission.

Authors:  Lisa B Haddad; Chelsea B Polis; Anandi N Sheth; Jennifer Brown; Athena P Kourtis; Caroline King; Rana Chakraborty; Igho Ofotokun
Journal:  Curr HIV/AIDS Rep       Date:  2014-12       Impact factor: 5.071

3.  A randomized clinical trial on the effects of progestin contraception in the genital tract of HIV-infected and uninfected women in Lilongwe, Malawi: Addressing evolving research priorities.

Authors:  Athena P Kourtis; Lisa Haddad; Jennifer Tang; Lameck Chinula; Stacey Hurst; Jeffrey Wiener; Sascha Ellington; Julie A E Nelson; Amanda Corbett; Kristina De Paris; Caroline C King; Mina Hosseinipour; Irving F Hoffman; Denise J Jamieson
Journal:  Contemp Clin Trials       Date:  2016-11-09       Impact factor: 2.226

4.  Persistent genital tract HIV-1 RNA shedding after change in treatment regimens in antiretroviral-experienced women with detectable plasma viral load.

Authors:  Kartik K Venkatesh; Allison K DeLong; Rami Kantor; Stacey Chapman; Jessica Ingersoll; Jaclynn Kurpewski; Maria Pia De Pasquale; Richard D'Aquila; Angela M Caliendo; Susan Cu-Uvin
Journal:  J Womens Health (Larchmt)       Date:  2013-03-26       Impact factor: 2.681

5.  RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

Authors:  Peter A Anton; Ross D Cranston; Angela Kashuba; Craig W Hendrix; Namandjé N Bumpus; Nicola Richardson-Harman; Julie Elliott; Laura Janocko; Elena Khanukhova; Robert Dennis; William G Cumberland; Chuan Ju; Alex Carballo-Diéguez; Christine Mauck; Ian McGowan
Journal:  AIDS Res Hum Retroviruses       Date:  2012-10-09       Impact factor: 2.205

6.  A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection.

Authors:  Jinquan Chen; Ruxia Ren; Suiyi Tan; Wanyue Zhang; Xuanxuan Zhang; Fei Yu; Tianrong Xun; Shibo Jiang; Shuwen Liu; Lin Li
Journal:  PLoS One       Date:  2015-12-14       Impact factor: 3.240

7.  HIV-1 RNA levels and antiretroviral drug resistance in blood and non-blood compartments from HIV-1-infected men and women enrolled in AIDS clinical trials group study A5077.

Authors:  Rami Kantor; Daniel Bettendorf; Ronald J Bosch; Marita Mann; David Katzenstein; Susan Cu-Uvin; Richard D'Aquila; Lisa Frenkel; Susan Fiscus; Robert Coombs
Journal:  PLoS One       Date:  2014-04-03       Impact factor: 3.240
  7 in total

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