Literature DB >> 21471430

Age-related macular degeneration and the other double helix. The Cogan Lecture.

Jayakrishna Ambati1.   

Abstract

The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD.

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Year:  2011        PMID： 21471430      PMCID： PMC3080169          DOI： 10.1167/iovs.11-7328

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  51 in total

1.  Bevacizumab for neovascular age related macular degeneration (ABC Trial): multicentre randomised double masked study.

Authors:  Adnan Tufail; Praveen J Patel; Catherine Egan; Philip Hykin; Lyndon da Cruz; Zdenek Gregor; Jonathan Dowler; Mohammed A Majid; Clare Bailey; Quresh Mohamed; Robert Johnston; Catey Bunce; Wen Xing
Journal:  BMJ       Date:  2010-06-09

Review 2.  Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.

Authors:  Jayakrishna Ambati; Balamurali K Ambati; Sonia H Yoo; Sean Ianchulev; Anthony P Adamis
Journal:  Surv Ophthalmol       Date:  2003 May-Jun       Impact factor: 6.048

Review 3.  The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis.

Authors:  Ryo Kawasaki; Miho Yasuda; Su Jeong Song; Shih-Jen Chen; Jost B Jonas; Jie Jin Wang; Paul Mitchell; Tien Y Wong
Journal:  Ophthalmology       Date:  2010-01-27       Impact factor: 12.079

4.  Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma.

Authors:  Mathieu Bergé; Philippe Bonnin; Eric Sulpice; José Vilar; David Allanic; Jean-Sébastien Silvestre; Bernard I Lévy; Gordon C Tucker; Gérard Tobelem; Tatyana Merkulova-Rainon
Journal:  Am J Pathol       Date:  2010-10-22       Impact factor: 4.307

5.  Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA.

Authors:  Liping Gu; Hui Chen; Jingsheng Tuo; Xiaowei Gao; Li Chen
Journal:  Exp Eye Res       Date:  2010-07-01       Impact factor: 3.467

6.  Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group.

Authors: 
Journal:  Arch Ophthalmol       Date:  1999-10

7.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

Authors:  S M Elbashir; J Harborth; W Lendeckel; A Yalcin; K Weber; T Tuschl
Journal:  Nature       Date:  2001-05-24       Impact factor: 49.962

8.  Risk factors for age-related macular degeneration: Pooled findings from three continents.

Authors:  W Smith; J Assink; R Klein; P Mitchell; C C Klaver; B E Klein; A Hofman; S Jensen; J J Wang; P T de Jong
Journal:  Ophthalmology       Date:  2001-04       Impact factor: 12.079

9.  Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.

Authors:  L Alexopoulou; A C Holt; R Medzhitov; R A Flavell
Journal:  Nature       Date:  2001-10-18       Impact factor: 49.962

10.  DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Authors:  Hiroki Kaneko; Sami Dridi; Valeria Tarallo; Bradley D Gelfand; Benjamin J Fowler; Won Gil Cho; Mark E Kleinman; Steven L Ponicsan; William W Hauswirth; Vince A Chiodo; Katalin Karikó; Jae Wook Yoo; Dong-ki Lee; Majda Hadziahmetovic; Ying Song; Smita Misra; Gautam Chaudhuri; Frank W Buaas; Robert E Braun; David R Hinton; Qing Zhang; Hans E Grossniklaus; Jan M Provis; Michele C Madigan; Ann H Milam; Nikki L Justice; Romulo J C Albuquerque; Alexander D Blandford; Sasha Bogdanovich; Yoshio Hirano; Jassir Witta; Elaine Fuchs; Dan R Littman; Balamurali K Ambati; Charles M Rudin; Mark M W Chong; Patrick Provost; Jennifer F Kugel; James A Goodrich; Joshua L Dunaief; Judit Z Baffi; Jayakrishna Ambati
Journal:  Nature       Date:  2011-02-06       Impact factor: 49.962
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  17 in total

1.  Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.

Authors:  Eric M Blalock; Heather M Buechel; Jelena Popovic; James W Geddes; Philip W Landfield
Journal:  J Chem Neuroanat       Date:  2011-07-02       Impact factor: 3.052

Review 2.  Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?

Authors:  Lisa Gherardini; Giuseppe Bardi; Mariangela Gennaro; Tommaso Pizzorusso
Journal:  Cell Mol Life Sci       Date:  2013-03-19       Impact factor: 9.261

3.  Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration.

Authors:  Haibo Wang; Erika S Wittchen; M Elizabeth Hartnett
Journal:  Eye Brain       Date:  2011-09-27

4.  MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

Authors:  Thomas R Sundermeier; Sanae Sakami; Bhubanananda Sahu; Scott J Howell; Songqi Gao; Zhiqian Dong; Marcin Golczak; Akiko Maeda; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2017-01-19       Impact factor: 5.157

Review 5.  Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration.

Authors:  Alexandre Vallée; Yves Lecarpentier; Rémy Guillevin; Jean-Noël Vallée
Journal:  J Mol Neurosci       Date:  2017-07-08       Impact factor: 3.444

6.  Genetics of age-related macular degeneration: application to drug design.

Authors:  Xi K Chu; Jingsheng Tuo; Chi-Chao Chan
Journal:  Future Med Chem       Date:  2013-01       Impact factor: 3.808

7.  670-nm light treatment reduces complement propagation following retinal degeneration.

Authors:  Matt Rutar; Riccardo Natoli; Rizalyn Albarracin; Krisztina Valter; Jan Provis
Journal:  J Neuroinflammation       Date:  2012-11-26       Impact factor: 8.322

8.  Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

Authors:  Erika S Wittchen; Eiichi Nishimura; Manabu McCloskey; Haibo Wang; Lawrence A Quilliam; Magdalena Chrzanowska-Wodnicka; M Elizabeth Hartnett
Journal:  PLoS One       Date:  2013-09-10       Impact factor: 3.240

9.  Socioeconomic Inequality of Non-Communicable Risk Factors among People Living in Kurdistan Province, Islamic Republic of Iran.

Authors:  Ghobad Moradi; Kazem Mohammad; Reza Majdzadeh; Hossein Malekafzali Ardakani; Kourosh Holakouie Naieni
Journal:  Int J Prev Med       Date:  2013-06

10.  Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina.

Authors:  Matt Rutar; Krisztina Valter; Riccardo Natoli; Jan M Provis
Journal:  PLoS One       Date:  2014-04-04       Impact factor: 3.240
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