Literature DB >> 21471232

Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.

Mildred Foster-Cuevas1, Tina Westerholt, Mohamed Ahmed, Marion H Brown, A Neil Barclay, Sebastian Voigt.   

Abstract

CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.

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Year:  2011        PMID： 21471232      PMCID： PMC3126311          DOI： 10.1128/JVI.00064-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

Authors:  R M Hoek; S R Ruuls; C A Murphy; G J Wright; R Goddard; S M Zurawski; B Blom; M E Homola; W J Streit; M H Brown; A N Barclay; J D Sedgwick
Journal:  Science       Date:  2000-12-01       Impact factor: 47.728

Review 2.  Poxviruses and immune evasion.

Authors:  Bruce T Seet; J B Johnston; Craig R Brunetti; John W Barrett; Helen Everett; Cheryl Cameron; Joanna Sypula; Steven H Nazarian; Alexandra Lucas; Grant McFadden
Journal:  Annu Rev Immunol       Date:  2001-12-19       Impact factor: 28.527

3.  Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.

Authors:  Mildred Foster-Cuevas; Gavin J Wright; Michael J Puklavec; Marion H Brown; A Neil Barclay
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

4.  The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht.

Authors:  Sebastian Voigt; Gordon R Sandford; Gary S Hayward; William H Burns
Journal:  J Gen Virol       Date:  2005-02       Impact factor: 3.891

5.  CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response.

Authors:  E Simelyte; S Alzabin; I Boudakov; R Williams
Journal:  Clin Exp Immunol       Date:  2010-10       Impact factor: 4.330

6.  Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia.

Authors:  Subhankar Mukhopadhyay; Annette Plüddemann; J Claire Hoe; Kevin J Williams; Audrey Varin; Katherine Makepeace; Marie-Laure Aknin; Dawn M E Bowdish; Stephen T Smale; A Neil Barclay; Siamon Gordon
Journal:  Cell Host Microbe       Date:  2010-09-16       Impact factor: 21.023

7.  Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.

Authors:  G J Wright; M J Puklavec; A C Willis; R M Hoek; J D Sedgwick; M H Brown; A N Barclay
Journal:  Immunity       Date:  2000-08       Impact factor: 31.745

8.  Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo.

Authors:  Cheryl M Cameron; John W Barrett; Liying Liu; Alexandra R Lucas; Grant McFadden
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

9.  Rat cytomegalovirus major immediate-early enhancer switching results in altered growth characteristics.

Authors:  G R Sandford; L E Brock; S Voigt; C M Forester; W H Burns
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

10.  2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.

Authors:  M H Brown; K Boles; P A van der Merwe; V Kumar; P A Mathew; A N Barclay
Journal:  J Exp Med       Date:  1998-12-07       Impact factor: 14.307
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  14 in total

1.  Herpesvirus orthologues of CD200 bind host CD200R but not related activating receptors.

Authors:  Lai Shan Kwong; Munir Akkaya; A Neil Barclay; Deborah Hatherley
Journal:  J Gen Virol       Date:  2015-11-04       Impact factor: 3.891

2.  Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation.

Authors:  Ryan D Estep; Aparna N Govindan; Kristin Fitzpatrick; Tiffany C Blair; S A Rahim Rezaee; David J Blackbourn; Scott W Wong
Journal:  J Virol       Date:  2020-12-16       Impact factor: 5.103

3.  Cellular distribution of CD200 receptor in rats and its interaction with cytomegalovirus e127 protein.

Authors:  Mohamed A El-Mokhtar; Agnieszka Bauer; Julia Madela; Sebastian Voigt
Journal:  Med Microbiol Immunol       Date:  2018-07-21       Impact factor: 3.402

4.  The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection.

Authors:  Ryan D Estep; Stephanie D Rawlings; Helen Li; Minsha Manoharan; Elizabeth T Blaine; Megan A O'Connor; Ilhem Messaoudi; Michael K Axthelm; Scott W Wong
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

Review 5.  Herpesvirus exploitation of host immune inhibitory pathways.

Authors:  Gabrielle Stack; Maria A Stacey; Ian R Humphreys
Journal:  Viruses       Date:  2012-08-03       Impact factor: 5.048

6.  Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells.

Authors:  Lai Shan Kwong; Marion H Brown; A Neil Barclay; Deborah Hatherley
Journal:  Immunology       Date:  2014-09       Impact factor: 7.397

Review 7.  The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions.

Authors:  Christine A Vaine; Roy J Soberman
Journal:  Adv Immunol       Date:  2014       Impact factor: 3.543

8.  Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution.

Authors:  Deborah Hatherley; Susan M Lea; Steven Johnson; A Neil Barclay
Journal:  Structure       Date:  2013-04-18       Impact factor: 5.006

9.  CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

Authors:  Gabrielle Stack; Emma Jones; Morgan Marsden; Maria A Stacey; Robert J Snelgrove; Paul Lacaze; Laura C Jacques; Simone M Cuff; Richard J Stanton; Awen M Gallimore; Tracy Hussell; Gavin W G Wilkinson; Peter Ghazal; Philip R Taylor; Ian R Humphreys
Journal:  PLoS Pathog       Date:  2015-02-05       Impact factor: 7.464

10.  Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses.

Authors:  Munir Akkaya; Lai-Shan Kwong; Erdem Akkaya; Deborah Hatherley; A Neil Barclay
Journal:  Virology       Date:  2015-11-17       Impact factor: 3.616
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