Literature DB >> 21468678

Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity.

Luca Errichiello1, Salvatore Striano, Federico Zara, Pasquale Striano.   

Abstract

Epilepsy is one of the most impactful diseases on social life. A significant number of epileptic syndromes have been linked to immunological alterations. Elevated levels of antibodies against glutamic acid decarboxylase have been recently found in a significant percentage of patients with temporal lobe epilepsy, the most common epilepsy type. The clinical and pathogenetic relationship of this association is discussed. This link may have important therapeutic implications and merits additional clinical and laboratory research.

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Year:  2011        PMID: 21468678     DOI: 10.1007/s10072-011-0566-8

Source DB:  PubMed          Journal:  Neurol Sci        ISSN: 1590-1874            Impact factor:   3.307


  39 in total

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Review 3.  GABAergic mechanisms in epilepsy.

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Journal:  Epilepsia       Date:  2001       Impact factor: 5.864

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Review 5.  Age-dependent vulnerability to seizures.

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8.  Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy.

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Journal:  Epilepsia       Date:  2009-10-08       Impact factor: 5.864

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Review 4.  Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?

Authors:  G Curia; C Lucchi; J Vinet; F Gualtieri; C Marinelli; A Torsello; L Costantino; G Biagini
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5.  Inhibition of glutamate decarboxylase (GAD) by ethyl ketopentenoate (EKP) induces treatment-resistant epileptic seizures in zebrafish.

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Review 6.  Diagnostic Value of Structural and Functional Neuroimaging in Autoimmune Epilepsy.

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7.  Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy.

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8.  GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.

Authors:  Suvi Liimatainen; Jerome Honnorat; Sean J Pittock; Andrew McKeon; Mario Manto; Jared R Radtke; Christiane S Hampe
Journal:  Orphanet J Rare Dis       Date:  2018-04-10       Impact factor: 4.123

  8 in total

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