Literature DB >> 21468393

A highly effective bifunctional ligand for radioimmunotherapy applications.

Hyun-Soon Chong1, Hyun A Song, Chi Soo Kang, Thien Le, Xiang Sun, Mamta Dadwal, Hyunbeom Lee, Xiaoli Lan, Yunwei Chen, Anzhi Dai.   

Abstract

A novel bifunctional ligand (3p-C-NETA) for antibody-targeted radioimmunotherapy (RIT) of β-emitting radioisotopes (90)Y and (177)Lu was efficiently synthesized via an unexpected regiospecific ring opening of an aziridinium ion. 3p-C-NETA instantly formed a very stable complex with (90)Y or (177)Lu. 3p-C-NETA is an excellent bifunctional ligand for RIT. © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21468393     DOI： 10.1039/c0cc05707j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Novel hexadentate and pentadentate chelators for ⁶⁴Cu-based targeted PET imaging.

Authors:  Inseok Sin; Chi Soo Kang; Nilantha Bandara; Xiang Sun; Yongliang Zhong; Buck E Rogers; Hyun-Soon Chong
Journal:  Bioorg Med Chem       Date:  2014-03-01       Impact factor: 3.641

2.  Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.

Authors:  Hyun-Soon Chong; Xiang Sun; Yunwei Chen; Inseok Sin; Chi Soo Kang; Michael R Lewis; Dijie Liu; Varyanna C Ruthengael; Yongliang Zhong; Ningjie Wu; Hyun A Song
Journal:  Bioorg Med Chem       Date:  2014-12-23       Impact factor: 3.641

3.  Efficient bifunctional decadentate ligand 3p-C-DEPA for targeted α-radioimmunotherapy applications.

Authors:  Hyun A Song; Chi Soo Kang; Kwamena E Baidoo; Diane E Milenic; Yunwei Chen; Anzhi Dai; M W Brechbiel; Hyun-Soon Chong
Journal:  Bioconjug Chem       Date:  2011-05-23       Impact factor: 4.774

4.  Coordination chemistry of [Y(pypa)]- and comparison immuno-PET imaging of [44Sc]Sc- and [86Y]Y-pypa-phenyl-TRC105.

Authors:  Lily Li; María de Guadalupe Jaraquemada-Peláez; Eduardo Aluicio-Sarduy; Xiaozhu Wang; Todd E Barnhart; Weibo Cai; Valery Radchenko; Paul Schaffer; Jonathan W Engle; Chris Orvig
Journal:  Dalton Trans       Date:  2020-04-09       Impact factor: 4.390

5.  Convenient Synthesis and Evaluation of Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications.

Authors:  Hyun-Soon Chong; Xiang Sun; Pengfei Dong; Chi Soo Kang
Journal:  European J Org Chem       Date:  2011-11-01

6.  Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using(90)Y or(177)Lu.

Authors:  Chi Soo Kang; Yunwei Chen; Hyunbeom Lee; Dijie Liu; Xiang Sun; Junghun Kweon; Michael R Lewis; Hyun-Soon Chong
Journal:  Nucl Med Biol       Date:  2014-10-20       Impact factor: 2.408

7.  Synthesis and preclinical evaluation of bifunctional ligands for improved chelation chemistry of 90Y and 177Lu for targeted radioimmunotherapy.

Authors:  Chi Soo Kang; Xiang Sun; Fang Jia; Hyun A Song; Yunwei Chen; Michael Lewis; Hyun-Soon Chong
Journal:  Bioconjug Chem       Date:  2012-08-10       Impact factor: 4.774

8.  Pyridine-containing octadentate ligand NE3TA-PY for formation of neutral complex with 177Lu(III) and 90Y(III) for radiopharmaceutical applications: Synthesis, DFT calculation, radiolabeling, and in vitro complex stability.

Authors:  Hyun-Soon Chong; Yunwei Chen; Chi Soo Kang; Inseok Sin; Shuyuan Zhang; Haixing Wang
Journal:  J Inorg Biochem       Date:  2021-04-24       Impact factor: 4.336

9.  A thiopyrylium salt for PET/NIR-II tumor imaging and image-guided surgery.

Authors:  Xiao Zhang; Bingbing Ding; Chunrong Qu; Huiling Li; Yu Sun; Yongkang Gai; Hao Chen; Hanyi Fang; Kun Qian; Yongxue Zhang; Zhen Cheng; Xiaoli Lan
Journal:  Mol Oncol       Date:  2020-04-07       Impact factor: 6.603

10.  New Bifunctional Chelator 3p-C-NEPA for Potential Applications in Lu(III) and Y(III) Radionuclide Therapy and Imaging.

Authors:  Xiang Sun; Chi Soo Kang; Inseok Sin; Shuyuan Zhang; Siyuan Ren; Haixing Wang; Dijie Liu; Michael R Lewis; Hyun-Soon Chong
Journal:  ACS Omega       Date:  2020-10-28
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